Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering
AbstractTissues in the body are hierarchically structured composite materials with tissue-specific chemical and topographical properties. Here we report the preparation of tissue scaffolds with macroscopic pores generated via the dissolution of a sacrificial supramolecular polymer-based crystal template (urea) from a biodegradable polymer-based scaffold (polycaprolactone, PCL). Furthermore, we report a method of aligning the supramolecular polymer-based crystals within the PCL, and that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale). The pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores. Generation of an interpenetrating network of polypyrrole (PPy) and poly(styrene sulfonate) (PSS) in the scaffolds yields electroactive tissue scaffolds that allow the electrical stimulation of Schwann cells cultured on the scaffolds which increases the production of nerve growth factor (NGF). View Full-Text
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Hardy, J.G.; Cornelison, R.C.; Sukhavasi, R.C.; Saballos, R.J.; Vu, P.; Kaplan, D.L.; Schmidt, C.E. Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering. Bioengineering 2015, 2, 15-34.
Hardy JG, Cornelison RC, Sukhavasi RC, Saballos RJ, Vu P, Kaplan DL, Schmidt CE. Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering. Bioengineering. 2015; 2(1):15-34.Chicago/Turabian Style
Hardy, John G.; Cornelison, R. C.; Sukhavasi, Rushi C.; Saballos, Richard J.; Vu, Philip; Kaplan, David L.; Schmidt, Christine E. 2015. "Electroactive Tissue Scaffolds with Aligned Pores as Instructive Platforms for Biomimetic Tissue Engineering." Bioengineering 2, no. 1: 15-34.