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Medicines 2017, 4(3), 61; doi:10.3390/medicines4030061

Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana

1
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, Germany
2
Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern, Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: João Rocha and Gerhard Litscher
Received: 30 July 2017 / Revised: 8 August 2017 / Accepted: 12 August 2017 / Published: 15 August 2017
(This article belongs to the Special Issue Herbal Medicines and Functional Foods)
View Full-Text   |   Download PDF [3137 KB, uploaded 17 August 2017]   |  

Abstract

Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS). Results: When tested in the model system Caenorhabditis elegans, the water extract from roasted guarana seeds enhanced resistance against oxidative stress, extended lifespan and attenuated aging markers such as muscle function decline and polyQ40 aggregation. Conclusions: In the current study, we demonstrate that guarana extracts can work as a powerful antioxidant in vivo; moreover, guarana extracts exhibit anti-aging properties. Our results suggest that the biological activities of guarana go beyond the extensively reported CNS stimulation. View Full-Text
Keywords: C. elegans; lifespan; oxidative stress; anti-aging; Paullinia cupana; guarana C. elegans; lifespan; oxidative stress; anti-aging; Paullinia cupana; guarana
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Peixoto, H.; Roxo, M.; Röhrig, T.; Richling, E.; Wang, X.; Wink, M. Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana. Medicines 2017, 4, 61.

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