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Medicines 2017, 4(3), 65; doi:10.3390/medicines4030065

Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu

1
Department of Biotechnology, Viva College, Mumbai 401303, Maharashtra, India
2
Department of Zoology, Sir Parashurambhau College, Pune 411030, Maharashtra, India
*
Author to whom correspondence should be addressed.
Academic Editor: Gerhard Litscher
Received: 19 July 2017 / Revised: 19 August 2017 / Accepted: 29 August 2017 / Published: 5 September 2017
(This article belongs to the Special Issue Herbal Medicines and Functional Foods)
View Full-Text   |   Download PDF [990 KB, uploaded 21 September 2017]   |  

Abstract

Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases. Natural antioxidants are in high demand because of their lesser side effects. This study aims to compare the antioxidant activity of aqueous and methanolic extracts of Acacia catechu—a traditional medicinal plant. Methods: The activity was examined using different in vitro systems including radical scavenging activity, lipid peroxidation and inhibition of OH radical induced DNA damage using standard protocols. Results: Both aqueous and methanolic extracts of Acacia catechu show significant activities with no differences in the efficacies of water and methanol soluble bioactive compounds. Conclusions: Present study revealed that aqueous extract of A. catechu has equal potential to be used as antioxidants as compared to methanolic extract. This can contribute to increased demand of physiologically compatible bioactive compounds of natural origin. View Full-Text
Keywords: Acacia catechu; aqueous extract and oxidative stress modulating activity; oxidative stress; in vitro assays for oxidative radical scavenging activity Acacia catechu; aqueous extract and oxidative stress modulating activity; oxidative stress; in vitro assays for oxidative radical scavenging activity
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Patil, A.; Modak, M. Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu. Medicines 2017, 4, 65.

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