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Medicines 2017, 4(3), 51; doi:10.3390/medicines4030051

Chemical Composition of Four Essential Oils of Eugenia from the Brazilian Amazon and Their Cytotoxic and Antioxidant Activity

1
Programa de Pós-Graduação em Biotecnologia, Universidade Federal do Pará, Belém 66075-110, Brazil
2
Programa de Pós-Graduação em Química, Universidade Federal do Pará, Belém 66075-110, Brazil
3
Coordenação de Botânica, Museu Paraense Emilio Goeldi, Belém 66077-530, Brazil
4
Laboratório de Citogenética Humana, Universidade Federal do Pará, Belém 66075-900, Brazil
5
Programa de Pós-Graduação em Recursos Naturais da Amazônia, Universidade Federal do Oeste do Pará, Santarém 68035-110, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Eleni Skaltsa and Gerhard Litscher
Received: 21 June 2017 / Revised: 5 July 2017 / Accepted: 5 July 2017 / Published: 8 July 2017
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Abstract

Background: Eugenia species are appreciated for their edible fruits and are known as having anticonvulsant, antimicrobial and insecticidal actions. Methods: The plant material was collected in the southeastern Pará state of Brazil and submitted to hydrodistillation. GC-MS analyzed the oils, and their antioxidant and cytotoxic activities were evaluated by the DPPH and MTT assays. Results: The main components identified in the Eugenia oils were 5-hydroxy-cis-calemene, (2E,6E)-farnesol, (2E,6Z)-farnesol, caryophylla-4(12),8(13)-dien-5α-ol-5β-ol, E-γ-bisabolene, β-bisabolene, germacrene D, and ishwarane. The oil of E. egensis showed the most significant antioxidant activity (216.5 ± 11.6 mg TE/mL), followed by the oils of E. flavescens (122.6 ± 6.8 mg TE/mL) and E. patrisii (111.2 ± 12.4 mg TE/mL). Eugenia oils were cytotoxic to HCT-116 (colon cancer) cells by the MTT assay, where the most active was the oil of E. polystachya (10.3 µg/mL), followed by the oils of E. flavescens (13.9 µg/mL) and E. patrisii (16.4 µg/mL). The oils of E. flavescens and E. patrisii showed the highest toxicity for MRC5 (human fibroblast) cells, with values of 14.0 µg/mL and 18.1 µg/mL, respectively. Conclusions: These results suggest that Eugenia oils could be tested in future studies for the treatment of colon cancer and oxidative stress management. View Full-Text
Keywords: Eugenia egensis; E. flavescens; E. patrisii; E. polystachya; Myrtaceae; essential oil; cytotoxicity; antioxidant activity Eugenia egensis; E. flavescens; E. patrisii; E. polystachya; Myrtaceae; essential oil; cytotoxicity; antioxidant activity
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MDPI and ACS Style

da Silva, J.K.R.; Andrade, E.H.A.; Barreto, L.H.; da Silva, N.C.F.; Ribeiro, A.F.; Montenegro, R.C.; Maia, J.G.S. Chemical Composition of Four Essential Oils of Eugenia from the Brazilian Amazon and Their Cytotoxic and Antioxidant Activity. Medicines 2017, 4, 51.

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