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Medicines 2017, 4(3), 49; doi:10.3390/medicines4030049

Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review

Parasitology Department, Institute of Tropical Medicine Pedro Kouri, 10400 Havana, Cuba
Department of Chemistry, Institute of Pharmacy and Food, University of Havana, 13600 Havana, Cuba
Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, 2610 Wilrijk, Belgium
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Author to whom correspondence should be addressed.
Academic Editor: Eleni Skaltsa
Received: 27 March 2017 / Revised: 28 June 2017 / Accepted: 28 June 2017 / Published: 2 July 2017
View Full-Text   |   Download PDF [1168 KB, uploaded 2 July 2017]   |  


Background: The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance. Terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. Methods: The essential oil (EO) of Piper aduncum L. (Piperaceae) from Cuba was analyzed by gas chromatography—mass spectrometry (GC-MS). A cluster analysis of P. aduncum EO compositions reported in the literature was carried out. The EO was screened against a panel of microorganisms (bacteria, fungi, parasitic protozoa) as well as for cytotoxicity against human cells. In addition, a review of scientific literature and a bibliometric study was also conducted. Results: A total of 90 compounds were identified in the EO, of which camphor (17.1%), viridiflorol (14.5%), and piperitone (23.7%) were the main components. The cluster analysis revealed at least nine different chemotypes. The EO did not show notable activity against bacteria or fungi, but was active against parasitic protozoa. Conclusions: The results from this study indicate P. aduncum from Cuba is a unique chemotype, support the importance of P. aduncum EOs as medicines, and demonstrate the promise of Cuban P. aduncum EO as a chemotherapeutic agent against parasitic protozoal infections. View Full-Text
Keywords: Piper aduncum; essential oil; cluster analysis; chemotypes; antimicrobial; parasitic protozoa Piper aduncum; essential oil; cluster analysis; chemotypes; antimicrobial; parasitic protozoa

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Monzote, L.; Scull, R.; Cos, P.; Setzer, W.N. Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review. Medicines 2017, 4, 49.

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