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Medicines 2017, 4(3), 48; doi:10.3390/medicines4030048

Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

School of Engineering, Ulster University, Jordanstown, Northern Ireland BT37 0QB, UK
Author to whom correspondence should be addressed.
Academic Editor: James D. Adams
Received: 22 May 2017 / Revised: 28 June 2017 / Accepted: 28 June 2017 / Published: 30 June 2017
View Full-Text   |   Download PDF [1318 KB, uploaded 30 June 2017]   |  


The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse. View Full-Text
Keywords: smart patches; methyl salicylate; toxicity; microneedle; transdermal smart patches; methyl salicylate; toxicity; microneedle; transdermal

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Anderson, A.; McConville, A.; Fanthorpe, L.; Davis, J. Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches. Medicines 2017, 4, 48.

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