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Toxics, Volume 7, Issue 2

2019 June - 18 articles

Cover Story: Proteins are subject to modification by electrophiles, giving insight into environmental agents and endogenous processes that may be contributing factors to chronic human diseases. Untargeted mass spectrometry approaches have been applied to blood proteins hemoglobin and albumin, focusing in particular on the N-terminal residue of hemoglobin and the cysteine-34 in albumin. In the current article, technical developments to detect simultaneously multiple adducts at these sites and then identify them are reviewed, along with recent studies monitoring human exposure to environmental toxicants. These methods have considerable potential for identifying the causes of human chronic disease and identifying individuals at risk. View this paper.
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Articles (18)

  • Feature Paper
  • Review
  • Open Access
6 Citations
5,155 Views
18 Pages

25 June 2019

As described elsewhere in this Special Issue on biomarkers, much progress has been made in the detection of modified DNA within organisms at endogenous and exogenous levels of exposure to chemical species, including putative carcinogens and chemother...

(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
  • Article
  • Open Access
23 Citations
5,261 Views
14 Pages

23 June 2019

Bisphenol S (BPS) is a common replacement for bisphenol A (BPA) in plastics, which has resulted in widespread human exposure. Type 1 diabetes (T1D) is an autoimmune disease resulting from pancreatic β-cell destruction and has been increasing in...

(This article belongs to the Section Toxicology)
  • Article
  • Open Access
16 Citations
5,830 Views
16 Pages

Heavy Metals in Biota in Delaware Bay, NJ: Developing a Food Web Approach to Contaminants

  • Joanna Burger,
  • Nellie Tsipoura,
  • Larry Niles,
  • Amanda Dey,
  • Christian Jeitner and
  • Michael Gochfeld

13 June 2019

Understanding the relationship between heavy metal and selenium levels in biota and their foods is important, but often difficult to determine because animals eat a variety of organisms. Yet such information is critical to managing species population...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Article
  • Open Access
31 Citations
6,462 Views
8 Pages

8 June 2019

Infant foods and formulae may contain toxic substances and elements which can be neo-formed contaminants or derived from raw materials or processing. The content of minerals, toxic elements, and hydroxymethylfurfural (HMF) in infant foods and formula...

(This article belongs to the Special Issue Analysis of Chemical Contaminants in Food)
  • Article
  • Open Access
14 Citations
4,833 Views
7 Pages

Levels of Cadmium in Human Mandibular Bone

  • Andrew W. Browar,
  • Landon L. Leavitt,
  • Walter C. Prozialeck and
  • Joshua R. Edwards

4 June 2019

Cadmium (Cd) is an environmental toxicant that accumulates in bone and alters bone turnover and metabolism. Periodontal disease is characterized by tooth loss and tissue destruction, specifically, loss of supporting bone around the teeth. We have pre...

(This article belongs to the Section Toxicology)
  • Feature Paper
  • Review
  • Open Access
46 Citations
14,972 Views
35 Pages

Bioanalytical and Mass Spectrometric Methods for Aldehyde Profiling in Biological Fluids

  • Romel P. Dator,
  • Morwena J. Solivio,
  • Peter W. Villalta and
  • Silvia Balbo

4 June 2019

Human exposure to aldehydes is implicated in multiple diseases including diabetes, cardiovascular diseases, neurodegenerative disorders (i.e., Alzheimer’s and Parkinson’s Diseases), and cancer. Because these compounds are strong electroph...

(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
  • Article
  • Open Access
28 Citations
5,794 Views
16 Pages

Quality Indicators and Possible Ecological Risks of Heavy Metals in the Sediments of three Semi-closed East Mediterranean Gulfs

  • Nikolaos Stamatis,
  • Nikolaos Kamidis,
  • Pelagia Pigada,
  • Georgios Sylaios and
  • Emmanouil Koutrakis

29 May 2019

Pollution with copper (Cu), lead (Pb), zinc (Zn), chromium (Cr), and nickel (Ni) heavy metals of the surface sediments collected from three semi-closed East Mediterranean Gulfs, namely Kavala, Strymonikos, and Ierissos Gulfs, North Aegean Sea, Greece...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Feature Paper
  • Review
  • Open Access
22 Citations
6,725 Views
17 Pages

25 May 2019

Proteins contain many sites that are subject to modification by electrophiles. Detection and characterisation of these modifications can give insights into environmental agents and endogenous processes that may be contributing factors to chronic huma...

(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
  • Article
  • Open Access
7 Citations
6,888 Views
9 Pages

Antioxidant and Cytoprotective Effect of Piper aduncum L. against Sodium Fluoride (NaF)-Induced Toxicity in Albino Mice

  • Oscar Herrera-Calderon,
  • Luz Chacaltana-Ramos,
  • Ricardo Ángel Yuli-Posadas,
  • Bertha Pari-Olarte,
  • Edwin Enciso-Roca,
  • Johnny Aldo Tinco-Jayo,
  • Juan Pedro Rojas-Armas,
  • Luis Miguel Visitación Felix-Veliz and
  • Cesar Franco-Quino

16 May 2019

Piper aduncum, commonly known as matico, is a plant that grows in the mountainous and coastal regions of Peru, and is studied for its antimicrobial properties and various ethnopharmacological uses. The main objective of this study was to determine th...

(This article belongs to the Section Toxicology)
  • Feature Paper
  • Review
  • Open Access
16 Citations
7,446 Views
22 Pages

Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science

  • Michael A. Malfatti,
  • Bruce A. Buchholz,
  • Heather A. Enright,
  • Benjamin J. Stewart,
  • Ted J. Ognibene,
  • A. Daniel McCartt,
  • Gabriela G. Loots,
  • Maike Zimmermann,
  • Tiffany M. Scharadin and
  • Kenneth W. Turteltaub
  • + 5 authors

This review summarizes recent developments in radiocarbon tracer technology and applications. Technologies covered include accelerator mass spectrometry (AMS), including conversion of samples to graphite, and rapid combustion to carbon dioxide to ena...

(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
  • Article
  • Open Access
11 Citations
7,927 Views
10 Pages

Patients with Parkinson’s disease (PD) have increased susceptibility to bisphenol A (BPA) exposure since they have an impaired biotransformation capacity to metabolize BPA. PD subjects have reduced levels of conjugated BPA compared to controls....

(This article belongs to the Section Toxicology)
  • Article
  • Open Access
15 Citations
7,334 Views
24 Pages

A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure

  • Aimée I. Vester,
  • Merry Chen,
  • Carmen J. Marsit and
  • W. Michael Caudle

Attention-deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood and previous studies indicate the dopamine system plays a major role in ADHD pathogenesis. Two environmental exposures independently a...

(This article belongs to the Collection Xenobiotics in Developmental Neurotoxicity)
  • Article
  • Open Access
10 Citations
4,879 Views
14 Pages

16 April 2019

The chemical structure of organophosphate compounds (OPs) is a well-known factor which modifies the acute toxicity of these compounds. We compared ventilation at rest and cholinesterase activities in male Sprague-Dawley rats poisoned with dimethyl pa...

(This article belongs to the Special Issue Toxicity of Chemical Mixtures)
  • Correction
  • Open Access
1 Citations
4,511 Views
3 Pages

11 April 2019

The authors wish to make the following corrections to this paper [...]

(This article belongs to the Section Toxicology)
  • Review
  • Open Access
691 Citations
36,343 Views
28 Pages

A Review of Biomonitoring of Phthalate Exposures

  • Yu Wang,
  • Hongkai Zhu and
  • Kurunthachalam Kannan

5 April 2019

Phthalates (diesters of phthalic acid) are widely used as plasticizers and additives in many consumer products. Laboratory animal studies have reported the endocrine-disrupting and reproductive effects of phthalates, and human exposure to this class...

(This article belongs to the Special Issue Biomarkers of Environmental Toxicants)
  • Article
  • Open Access
35 Citations
7,375 Views
19 Pages

Protective Effects of Centella asiatica on Cognitive Deficits Induced by D-gal/AlCl3 via Inhibition of Oxidative Stress and Attenuation of Acetylcholinesterase Level

  • Samaila Musa Chiroma,
  • Mohamad Taufik Hidayat Baharuldin,
  • Che Norma Mat Taib,
  • Zulkhairi Amom,
  • Saravanan Jagadeesan,
  • Mohd Ilham Adenan,
  • Onesimus Mahdi and
  • Mohamad Aris Mohd Moklas

30 March 2019

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cholinergic dysfunctions and impaired redox homeostasis. The plant Centella asiatica (CA) is renowned for its nutritional benefits and herbal formulas for promoting healt...

(This article belongs to the Special Issue Toxicity of Chemical Mixtures)
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Toxics - ISSN 2305-6304