Inorganics 2014, 2(1), 96-114; doi:10.3390/inorganics2010096
Review

Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs

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Received: 7 January 2014; in revised form: 20 February 2014 / Accepted: 27 February 2014 / Published: 21 March 2014
(This article belongs to the Special Issue Innovative Inorganic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The continuous rising of the cancer patient death rate undoubtedly shows the pressure to find more potent and efficient drugs than those in clinical use. These agents only treat a narrow range of cancer conditions with limited success and are associated with serious side effects caused by the lack of selectivity. In this frame, innovative syntheses approaches can decisively contribute to the success of “smart compounds” that might be only selective and/or active towards the cancer cells, sparing the healthy ones. In this scope, ruthenium chemistry is a rising field for the search of proficient metallodrugs by the use of macromolecular ruthenium complexes (dendrimers and dendronized polymers, coordination-cage and protein conjugates, nanoparticles and polymer-“ruthenium-cyclopentadienyl” conjugates) that can take advantage of the singularities of tumor cells (vs. healthy cells).
Keywords: ruthenium; arene-derivatives; conjugates; multinuclear; organometallics; cytotoxicity; chemotherapy; anticancer; EPR effect
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MDPI and ACS Style

Valente, A.; Garcia, M.H. Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs. Inorganics 2014, 2, 96-114.

AMA Style

Valente A, Garcia MH. Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs. Inorganics. 2014; 2(1):96-114.

Chicago/Turabian Style

Valente, Andreia; Garcia, M. H. 2014. "Syntheses of Macromolecular Ruthenium Compounds: A New Approach for the Search of Anticancer Drugs." Inorganics 2, no. 1: 96-114.

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