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Separations 2016, 3(4), 28; doi:10.3390/separations3040028

Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse

Centre for Research in Biosciences, Department of Applied Sciences, University of the West of England, Frenchay Campus, Coldharbour Lane, Bristol BS16 1QY, UK
Academic Editor: Frank L. Dorman
Received: 22 June 2016 / Revised: 11 August 2016 / Accepted: 29 August 2016 / Published: 22 September 2016
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Abstract

This review (4 tables, 88 references) describes current developments in the design and application of liquid chromatography electrochemical detection (LC ED) based approaches for the determination of drugs of abuse. Specific emphasis is placed on operating details and performance characteristics for selected applications. LC ED has been shown to be highly sensitive and specific as well being a more economic option. A wide range of abused substances have been determined using this approach, including: cannabinoids, ethanol, opiates, morphine, mushroom toxins, benzodiazepines and several legal highs. Reverse-phase liquid chromatography with either amperometric or coulometric determination has been the most commonly reported applications. However, coulometric arrays have been also reported. Detection limits in the ng/mL region have been reported for most target analytes. View Full-Text
Keywords: cannabinoids; ethanol; opiates; morphine; mushroom toxins; benzodiazepines; legal highs; liquid chromatography; electrochemical detection cannabinoids; ethanol; opiates; morphine; mushroom toxins; benzodiazepines; legal highs; liquid chromatography; electrochemical detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Honeychurch, K. Review: The Application of Liquid Chromatography Electrochemical Detection for the Determination of Drugs of Abuse. Separations 2016, 3, 28.

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