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Children 2015, 2(3), 382-402; doi:10.3390/children2030382

The Role of Skin Barrier in the Pathogenesis of Food Allergy

1
Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA
2
Department of Dermatology, Keck School of Medicine, University of Southern California
3
Division of Clinical Immunology and Allergy, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jonathan M. Spergel
Received: 1 June 2015 / Revised: 25 August 2015 / Accepted: 25 August 2015 / Published: 2 September 2015
(This article belongs to the Special Issue Recent Advances in Pediatric Food Allergy)
View Full-Text   |   Download PDF [233 KB, uploaded 4 September 2015]

Abstract

Food allergy is a serious public health problem with an increasing prevalence. Current management is limited to food avoidance and emergency treatment. Research into the pathogenesis of food allergy has helped to shape our understanding of how patients become sensitized to an allergen. Classically, food sensitization was thought to occur through the gastrointestinal tract, but alternative routes of sensitization are being explored, specifically through the skin. Damaged skin barrier may play a crucial role in the development of food sensitization. Better understanding of how patients initially become sensitized may help lead to the development of a safe and effective treatment for food allergies or better prevention strategies. View Full-Text
Keywords: food allergy; skin barrier; allergic sensitization; filaggrin food allergy; skin barrier; allergic sensitization; filaggrin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Izadi, N.; Luu, M.; Ong, P.Y.; Tam, J.S. The Role of Skin Barrier in the Pathogenesis of Food Allergy. Children 2015, 2, 382-402.

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