Next Article in Journal
Climate Change and Children’s Health: A Commentary
Next Article in Special Issue
Functional Nausea in Children: A Review of the Literature and Need for Diagnostic Criteria
Previous Article in Journal
The Role of Skin Barrier in the Pathogenesis of Food Allergy
Previous Article in Special Issue
Controversies in the Mechanism of Total Parenteral Nutrition Induced Pathology
Article Menu

Export Article

Open AccessArticle
Children 2015, 2(4), 403-411; doi:10.3390/children2040403

Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada

1
Department of Pediatrics, Drexel University College of Medicine and St. Christopher’s Hospital for Children, Philadelphia, PA, 19130, USA
2
Janeway Pediatric Research Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada, A1B 3V6
3
Department of Laboratory Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada, A1B 3V6
*
Author to whom correspondence should be addressed.
Academic Editor: Sari Acra
Received: 26 June 2015 / Revised: 31 August 2015 / Accepted: 23 September 2015 / Published: 14 October 2015
(This article belongs to the Collection Controversies in Pediatric Digestive Diseases)
View Full-Text   |   Download PDF [159 KB, uploaded 15 October 2015]

Abstract

Objectives: The objectives of this study were to establish the prevalence of positive antibodies to endomysium (EMA) and tissue transglutaminase (tTG) in children with type 1 diabetes living in Newfoundland and Labrador (NL), and to examine clinical features associated with positive antibodies. Methods: Patients were recruited from the pediatric diabetes clinic. One hundred sixty-seven children with type 1 diabetes from the 280 children followed at the clinic were prospectively screened for celiac disease using EMA and tTG. The variables of Irish descent, age at onset of diabetes, duration of diabetes, sex, family history of celiac disease, hemoglobin A1C (A1C), ferritin, gastrointestinal symptoms, and body mass index were compiled for all patients. The group of patients with positive antibodies to EMA and/or tTG was compared to the group with negative antibodies. Results: The prevalence of patients with positive antibodies to EMA and/or tTG was 16.8% (n = 28). One patient had also been previously diagnosed with symptomatic celiac disease. The two statistically significant variables with positive antibodies were an earlier age at onset of diabetes (Mann-Whitney U two-tailed test: mean difference 3.2 years, 95% CI 1.7–4.8 years, p < 0.0001) and longer duration of diabetes (Mann-Whitney U two-tailed test: mean difference 2.9 years, 95% CI 1.3–4.4 years, p < 0.0001). Irish descent was associated with positive antibodies but did not reach statistical significance. On logistic regression analysis performed with these three variables together, only age at onset of diabetes remained significant. Conclusions: There is a high prevalence of celiac disease-associated antibodies in children living in NL with type 1 diabetes. Unlike other clinical features, an earlier age at onset of diabetes was predictive for positive antibodies. As the majority of children with positive antibodies did not have signs or symptoms of celiac disease, routine screening for celiac disease in type 1 diabetes is recommended. View Full-Text
Keywords: Celiac disease; pediatrics; type 1 diabetes Celiac disease; pediatrics; type 1 diabetes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Pall, H.; Newhook, L.A.; Aaron, H.; Curtis, J.; Randell, E. Young Age at Diagnosis of Type 1 Diabetes Is Associated with the Development of Celiac Disease—Associated Antibodies in Children Living in Newfoundland and Labrador, Canada. Children 2015, 2, 403-411.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top