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Children 2015, 2(3), 371-381; doi:10.3390/children2030371

Egg Food Challenges are Associated with More Gastrointestinal Reactions

1
Department of Pediatrics, Division of Allergy and Immunology, The Children’s Hospital of Philadelphia, 3550 Market Street, Philadelphia, PA 19104-4399, USA
2
Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104-4399, USA
3
Tel-Aviv University, Tel Aviv 69978, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Sari Acra
Received: 3 June 2015 / Revised: 19 July 2015 / Accepted: 24 July 2015 / Published: 17 August 2015
(This article belongs to the Special Issue Recent Advances in Pediatric Food Allergy)
View Full-Text   |   Download PDF [210 KB, uploaded 17 August 2015]   |  

Abstract

Egg allergy is a common pediatric allergy, and is usually outgrown by elementary school age. There is, therefore, a need to perform an oral food challenge (OFC) to establish the presence of food allergy to egg. In this study, we conducted a retrospective review of 2304 OFCs at a pediatric center and analyzed the severity of reactions during egg OFCs and compared them with other foods. The gastrointestinal system (GI) has been reported as more affected in egg food challenge. This study confirmed that 11% of patients undergoing egg OFC had GI symptoms vs. 7% undergoing food challenges for other foods or compared to milk, peanut and tree nut, individually. However, the involvement of lower respiratory tract was less frequent with egg than observed in peanut and tree nut OFC and similar to observed rate in milk. In conclusion, our study confirmed that OFC to egg causes more GI symptoms and less respiratory symptoms compared to other foods, in particular peanuts and tree nuts. However, 27% of children who failed egg OFC had lower respiratory tract reactions and required the use of epinephrine, similarly to children undergoing milk challenge. View Full-Text
Keywords: egg allergy; epinephrine; gastrointestinal; skin prick testing; oral food challenge egg allergy; epinephrine; gastrointestinal; skin prick testing; oral food challenge
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gupta, M.; Grossmann, L.D.; Spergel, J.M.; Cianferoni, A. Egg Food Challenges are Associated with More Gastrointestinal Reactions. Children 2015, 2, 371-381.

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