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Children 2015, 2(4), 424-438;

Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition

Department of Pediatrics, Children’s Hospital Teresa Herrera, A Coruña University Hospital, Xubias de Arriba 84, 15006 La Coruña, Spain
Division of Pediatric Allergy and Immunology and the Jaffe Food Allergy Institute, The Mount Sinai School of Medicine, New York, 10029-6574, NY, USA
Author to whom correspondence should be addressed.
Academic Editor: Jonathan M. Spergel
Received: 25 June 2015 / Revised: 24 September 2015 / Accepted: 2 October 2015 / Published: 19 October 2015
(This article belongs to the Special Issue Recent Advances in Pediatric Food Allergy)
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Kiwifruit allergy has been described mostly in the adult population, but immunoglobulin (Ig)E-mediated allergic reactions to kiwifruit appear to be occurring more frequently in children. To date, 13 allergens from kiwifruit have been identified. Our aim was to identify kiwifruit allergens in a kiwifruit allergic-pediatric population, describing clinical manifestations and patterns of recognition. Twenty-four children were included. Diagnosis of kiwifruit allergy was based on compatible clinical manifestations and demonstration of specific IgE by skin prick test (SPT) and/or serum-specific IgE determination. SDS-PAGE and immunoblotting were performed with kiwifruit extract, and proteins of interest were further analyzed by mass spectrometry/mass spectrometry. For component-resolved in vitro diagnosis, sera of kiwifruit-allergic patients were analyzed by an allergen microarray assay. Act d 1 and Act d 2 were bound by IgE from 15 of 24 children. Two children with systemic manifestations recognized a protein of 15 kDa, homologous to Act d 5. Act d 1 was the allergen with the highest frequency of recognition on microarray chip, followed by Act d 2 and Act d 8. Kiwifruit allergic children develop systemic reactions most frequently following ingestion compared to adults. Act d 1 and Act d 2 are major allergens in the pediatric age group. View Full-Text
Keywords: actinidin; SDS-PAGE immunoblotting; pediatric; kiwifruit; food allergy actinidin; SDS-PAGE immunoblotting; pediatric; kiwifruit; food allergy

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Moreno Álvarez, A.; Sexto, L.V.; Bardina, L.; Grishina, G.; Sampson, H.A. Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition. Children 2015, 2, 424-438.

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