Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition
AbstractKiwifruit allergy has been described mostly in the adult population, but immunoglobulin (Ig)E-mediated allergic reactions to kiwifruit appear to be occurring more frequently in children. To date, 13 allergens from kiwifruit have been identified. Our aim was to identify kiwifruit allergens in a kiwifruit allergic-pediatric population, describing clinical manifestations and patterns of recognition. Twenty-four children were included. Diagnosis of kiwifruit allergy was based on compatible clinical manifestations and demonstration of specific IgE by skin prick test (SPT) and/or serum-specific IgE determination. SDS-PAGE and immunoblotting were performed with kiwifruit extract, and proteins of interest were further analyzed by mass spectrometry/mass spectrometry. For component-resolved in vitro diagnosis, sera of kiwifruit-allergic patients were analyzed by an allergen microarray assay. Act d 1 and Act d 2 were bound by IgE from 15 of 24 children. Two children with systemic manifestations recognized a protein of 15 kDa, homologous to Act d 5. Act d 1 was the allergen with the highest frequency of recognition on microarray chip, followed by Act d 2 and Act d 8. Kiwifruit allergic children develop systemic reactions most frequently following ingestion compared to adults. Act d 1 and Act d 2 are major allergens in the pediatric age group. View Full-Text
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Moreno Álvarez, A.; Sexto, L.V.; Bardina, L.; Grishina, G.; Sampson, H.A. Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition. Children 2015, 2, 424-438.
Moreno Álvarez A, Sexto LV, Bardina L, Grishina G, Sampson HA. Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition. Children. 2015; 2(4):424-438.Chicago/Turabian Style
Moreno Álvarez, Ana; Sexto, Leticia V.; Bardina, Luda; Grishina, Galina; Sampson, Hugh. A. 2015. "Kiwifruit Allergy in Children: Characterization of Main Allergens and Patterns of Recognition." Children 2, no. 4: 424-438.