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J. Dev. Biol. 2016, 4(3), 25; doi:10.3390/jdb4030025

A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint

Edinburgh CRUK Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh EH4 2XR, UK
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Academic Editors: Henk Roelink and Simon J. Conway
Received: 27 June 2016 / Revised: 8 August 2016 / Accepted: 17 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

This review highlights the essential role of Hedgehog (Hh) signalling in the developmental steps of temporomandibular joint (TMJ) formation. We review evidence for intra- and potentially inter-tissue Hh signaling as well as Glioma-Associated Oncogene Homolog (GLI) dependent and independent functions. Morphogenesis and maturation of the TMJ’s individual components and the general landscape of Hh signalling is also covered. Comparison of the appendicular knee and axial TMJ also reveals interesting differences and similarities in their mechanisms of development, chondrogenesis and reliance on Hh signalling. View Full-Text
Keywords: Hedgehog; Hh; Indian Hedgehog; IHH; temporomandibular joint; synovial joint; GLI Hedgehog; Hh; Indian Hedgehog; IHH; temporomandibular joint; synovial joint; GLI
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kubiak, M.; Ditzel, M. A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint. J. Dev. Biol. 2016, 4, 25.

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