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J. Dev. Biol. 2016, 4(3), 26; doi:10.3390/jdb4030026

Hedgehog Promotes Production of Inhibitory Interneurons in Vivo and in Vitro from Pluripotent Stem Cells

Department of Biology, Wesleyan University, 52 Lawn Avenue, Middletown, CT 06459, USA
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Academic Editors: Henk Roelink and Simon J. Conway
Received: 11 July 2016 / Revised: 10 August 2016 / Accepted: 17 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
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Abstract

Loss or damage of cortical inhibitory interneurons characterizes a number of neurological disorders. There is therefore a great deal of interest in learning how to generate these neurons from a pluripotent stem cell source so they can be used for cell replacement therapies or for in vitro drug testing. To design a directed differentiation protocol, a number of groups have used the information gained in the last 15 years detailing the conditions that promote interneuron progenitor differentiation in the ventral telencephalon during embryogenesis. The use of Hedgehog peptides and agonists is featured prominently in these approaches. We review here the data documenting a role for Hedgehog in specifying interneurons in both the embryonic brain during development and in vitro during the directed differentiation of pluripotent stem cells. View Full-Text
Keywords: Sonic hedgehog; GABAergic interneurons; medial ganglionic eminence; pluripotent stem cells Sonic hedgehog; GABAergic interneurons; medial ganglionic eminence; pluripotent stem cells
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MDPI and ACS Style

Anderson, N.C.; Chen, C.Y.; Grabel, L. Hedgehog Promotes Production of Inhibitory Interneurons in Vivo and in Vitro from Pluripotent Stem Cells. J. Dev. Biol. 2016, 4, 26.

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