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J. Dev. Biol. 2016, 4(3), 24; doi:10.3390/jdb4030024

The Role of Sonic Hedgehog in Craniofacial Patterning, Morphogenesis and Cranial Neural Crest Survival

1
Department of Medicine, Monash University Central Clinical School, Prahran, Victoria 3004, Australia
2
Department of Physiology, Anatomy and Microbiology, La Trobe University, Melbourne, Victoria 3086, Australia
3
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia
4
Department of Surgery, Monash University Central Clinical School, Prahran, Victoria 3004, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Simon J. Conway
Received: 7 June 2016 / Revised: 20 July 2016 / Accepted: 26 July 2016 / Published: 3 August 2016
(This article belongs to the Special Issue Hedgehog Signaling in Embryogenesis)
View Full-Text   |   Download PDF [2028 KB, uploaded 3 August 2016]   |  

Abstract

Craniofacial defects (CFD) are a significant healthcare problem worldwide. Understanding both the morphogenetic movements which underpin normal facial development, as well as the molecular factors which regulate these processes, forms the cornerstone of future diagnostic, and ultimately, preventative therapies. The soluble morphogen Sonic hedgehog (Shh), a vertebrate orthologue of Drosophila hedgehog, is a key signalling factor in the regulation of craniofacial skeleton development in vertebrates, operating within numerous tissue types in the craniofacial primordia to spatiotemporally regulate the formation of the face and jaws. This review will provide an overview of normal craniofacial skeleton development, and focus specifically on the known roles of Shh in regulating the development and progression of the first pharyngeal arch, which in turn gives rise to both the upper jaw (maxilla) and lower jaw (mandible). View Full-Text
Keywords: Hedgehog; neural crest; craniofacial; maxilla; mandible; development; cleft palate Hedgehog; neural crest; craniofacial; maxilla; mandible; development; cleft palate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dworkin, S.; Boglev, Y.; Owens, H.; Goldie, S.J. The Role of Sonic Hedgehog in Craniofacial Patterning, Morphogenesis and Cranial Neural Crest Survival. J. Dev. Biol. 2016, 4, 24.

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J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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