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J. Dev. Biol. 2014, 2(2), 138-157; doi:10.3390/jdb2020138
Review

Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development

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 and *
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, México DF 04510, Mexico Present Address: Laboratorio de Tejido Conjuntivo, Centro de Investigación y Atención al Quemado, Instituto Nacional de Rehabilitación, Av. México-Xochimilco 289, México DF 14389, Mexico
* Author to whom correspondence should be addressed.
Received: 31 January 2014 / Revised: 14 April 2014 / Accepted: 15 April 2014 / Published: 29 April 2014
(This article belongs to the Special Issue Retinoids in Development)
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Abstract

The precise coordination of cell death and cell differentiation during the formation of developing digits is essential for generating properly shaped limbs. Retinoic acid (RA) has a fundamental role in digit development; it promotes or inhibits the molecular expression of several critical genes. This control of gene expression establishes molecular cascades that enable both the commencement of cell death and the inhibition of cell differentiation. In this review, we focus on the antagonistic functions between RA and fibroblast growth factor (FGF) signaling in the control of cell death and between RA and transforming growth factor beta (TGFβ) signaling in the control of cell differentiation.
Keywords: interdigital cell death; retinoic acid; limb development; digit formation; apoptosis; FGF; TGFβ interdigital cell death; retinoic acid; limb development; digit formation; apoptosis; FGF; TGFβ
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Díaz-Hernández, M.E.; Rios-Flores, A.J.; Abarca-Buis, R.F.; Bustamante, M.; Chimal-Monroy, J. Molecular Control of Interdigital Cell Death and Cell Differentiation by Retinoic Acid during Digit Development. J. Dev. Biol. 2014, 2, 138-157.

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