J. Dev. Biol. 2014, 2(2), 101-116; doi:10.3390/jdb2020101

The Epicardium in the Embryonic and Adult Zebrafish

, 1,2,3,†
, 1
 and 1,*
Received: 8 February 2014; in revised form: 24 February 2014 / Accepted: 26 February 2014 / Published: 11 April 2014
(This article belongs to the Special Issue Epicardial Development and Cardiovascular Disease)
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Abstract: The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms’ tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation.
Keywords: proepicardium; epicardium; zebrafish; development; regeneration; wt1a; wt1b
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Peralta, M.; González-Rosa, J.M.; Marques, I.J.; Mercader, N. The Epicardium in the Embryonic and Adult Zebrafish. J. Dev. Biol. 2014, 2, 101-116.

AMA Style

Peralta M, González-Rosa JM, Marques IJ, Mercader N. The Epicardium in the Embryonic and Adult Zebrafish. Journal of Developmental Biology. 2014; 2(2):101-116.

Chicago/Turabian Style

Peralta, Marina; González-Rosa, Juan M.; Marques, Inês J.; Mercader, Nadia. 2014. "The Epicardium in the Embryonic and Adult Zebrafish." J. Dev. Biol. 2, no. 2: 101-116.

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