Functional Amyloids in Reproduction
AbstractAmyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes. In this review, we will specifically describe amyloids that carry out biological roles in sexual reproduction including the processes of gametogenesis, germline specification, sperm maturation and fertilization. Several of these functional amyloids are evolutionarily conserved across several taxa, including human, emphasizing the critical role amyloids perform in reproduction. Evidence will also be presented suggesting that, if altered, some functional amyloids may become pathological. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Hewetson, A.; Do, H.Q.; Myers, C.; Muthusubramanian, A.; Sutton, R.B.; Wylie, B.J.; Cornwall, G.A. Functional Amyloids in Reproduction. Biomolecules 2017, 7, 46.
Hewetson A, Do HQ, Myers C, Muthusubramanian A, Sutton RB, Wylie BJ, Cornwall GA. Functional Amyloids in Reproduction. Biomolecules. 2017; 7(3):46.Chicago/Turabian Style
Hewetson, Aveline; Do, Hoa Quynh; Myers, Caitlyn; Muthusubramanian, Archana; Sutton, Roger Bryan; Wylie, Benjamin J.; Cornwall, Gail A. 2017. "Functional Amyloids in Reproduction." Biomolecules 7, no. 3: 46.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.