Next Article in Journal
Repair of DNA Double-Strand Breaks in Heterochromatin
Next Article in Special Issue
DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge
Previous Article in Journal / Special Issue
The Emergence of Pan-Cancer CIMP and Its Elusive Interpretation
Article Menu

Export Article

Open AccessReview
Biomolecules 2016, 6(4), 46; doi:10.3390/biom6040046

Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis

1
Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India
2
Department of Otorhinolaryngology-Head and Neck Surgery, and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Gerda Egger and Melanie R. Hassler
Received: 20 September 2016 / Revised: 2 November 2016 / Accepted: 7 November 2016 / Published: 24 November 2016
(This article belongs to the Special Issue DNA Methylation and Cancer)
View Full-Text   |   Download PDF [1301 KB, uploaded 24 November 2016]   |  

Abstract

Epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. Epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. Epstein-Barr virus (EBV), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers—both of epithelial and lymphoid origin. The cell type-dependent different EBV latent gene expression patterns appear to be determined by the cellular epigenetic machinery and similarly viral oncoproteins recruit epigenetic regulators in order to deregulate the cellular gene expression profile resulting in several human cancers. This review elucidates the epigenetic consequences of EBV–host interactions during development of multiple EBV-induced B-cell lymphomas, which may lead to the discovery of novel therapeutic interventions against EBV-associated B-cell lymphomas by alteration of reversible patho-epigenetic markings. View Full-Text
Keywords: Epstein-Barr virus; B-cell lymphoma; Epigenetics Epstein-Barr virus; B-cell lymphoma; Epigenetics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ghosh Roy, S.; Robertson, E.S.; Saha, A. Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis. Biomolecules 2016, 6, 46.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top