Special Issue "DNA Methylation and Cancer"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 August 2016)
Dr. Melanie R. Hassler
The field of epigenetics has been the focus of diverse research fields in recent years. It has become clear that epigenetic mechanisms are causally involved in tumorigenesis. Mutations of epigenetic enzymes are frequently found in cancer and especially aberrant patterns of DNA methylation have been extensively explored. Global hypomethylation and local hypermethylation of CpG islands are the hallmarks of the cancer methylome resulting in genomic instability and silencing of underlying genes, respectively. The CpG island methylator phenotype (CIMP) corresponds to certain patient and tumor characteristics, which makes aberrant DNA methylation a promising target for biomarker development. Great hope lies in the field of non-invasive cancer diagnostics using circulating free tumor DNA isolated from liquid biopsies and tumor-specific DNA methylation is a suitable marker for these approaches. Additionally, epigenetic drugs including DNA methyltransferase inhibitors are successfully used in the clinics. Currently a wide range of epigenetic inhibitors are developed and tested in preclinical and clinical studies.
We invite scientists focusing on DNA methylation and cancer to submit their original work or reviews, covering studies on the mechanisms of aberrant DNA methylation in cancer, epigenetic biomarkers or epigenetic therapy. Both translational and basic research papers are welcome.
Prof. Dr. Gerda Egger
Dr. Melanie R. Hassler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- DNA methylation and cancer
- Epigenomic profiling in cancer
- DNA methylation biomarkers
- Epigenetic therapy
- DNMT inhibitors