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Biomolecules 2016, 6(4), 47; doi:10.3390/biom6040047

Repair of DNA Double-Strand Breaks in Heterochromatin

Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RR , UK
Academic Editor: Rob de Bruin
Received: 18 October 2016 / Revised: 25 November 2016 / Accepted: 5 December 2016 / Published: 16 December 2016
(This article belongs to the Special Issue Chromosome Maintenance)
View Full-Text   |   Download PDF [2492 KB, uploaded 16 December 2016]   |  

Abstract

DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or chromosomal rearrangements. DSBs can be in the form of simple or complex breaks, and may be repaired by one of a number of processes, the nature of which depends on the complexity of the break or the position of the break within the chromatin. In eukaryotic cells, nuclear DNA is maintained as either euchromatin (EC) which is loosely packed, or in a denser form, much of which is heterochromatin (HC). Due to the less accessible nature of the DNA in HC as compared to that in EC, repair of damage in HC is not as straightforward as repair in EC. Here we review the literature on how cells deal with DSBs in HC. View Full-Text
Keywords: HP1; 53BP1; BRCA1; γH2AX; homologous recombination; c-NHEJ; alt-NHEJ HP1; 53BP1; BRCA1; γH2AX; homologous recombination; c-NHEJ; alt-NHEJ
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Watts, F.Z. Repair of DNA Double-Strand Breaks in Heterochromatin. Biomolecules 2016, 6, 47.

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