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Biomolecules 2015, 5(4), 3051-3066; doi:10.3390/biom5043051

Expression and Function of CD44 in Epithelial Ovarian Carcinoma

Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA
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Author to whom correspondence should be addressed.
Academic Editor: Jürg Bähler
Received: 30 September 2015 / Revised: 29 October 2015 / Accepted: 30 October 2015 / Published: 11 November 2015
(This article belongs to the Special Issue Signal Transduction Pathways in Gynecologic Malignancies)
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Abstract

CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed. View Full-Text
Keywords: CD44; epithelial ovarian carcinoma; hyaluronan; adhesion; metastasis; cancer stem cells CD44; epithelial ovarian carcinoma; hyaluronan; adhesion; metastasis; cancer stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sacks, J.D.; Barbolina, M.V. Expression and Function of CD44 in Epithelial Ovarian Carcinoma. Biomolecules 2015, 5, 3051-3066.

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