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Biomolecules 2015, 5(4), 3260-3279; doi:10.3390/biom5043260

The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer

1
Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon EX1 2LU, UK
2
Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon EX2 7JU, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Barbolina
Received: 7 October 2015 / Accepted: 13 November 2015 / Published: 20 November 2015
(This article belongs to the Special Issue Signal Transduction Pathways in Gynecologic Malignancies)
View Full-Text   |   Download PDF [359 KB, uploaded 20 November 2015]   |  

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and has a poor prognosis due to relatively unspecific early symptoms, and thus often advanced stage, metastasized cancer at presentation. Metastasis of EOC occurs primarily through the transcoelomic route whereby exfoliated tumor cells disseminate within the abdominal cavity, particularly to the omentum. Primary and metastatic tumor growth requires a pool of proangiogenic factors in the microenvironment which propagate new vasculature in the growing cancer. Recent evidence suggests that proangiogenic factors other than the widely known, potent angiogenic factor vascular endothelial growth factor may mediate growth and metastasis of ovarian cancer. In this review we examine the role of some of these alternative factors, specifically cathepsin D and cathepsin L. View Full-Text
Keywords: epithelial ovarian cancer; angiogenesis; metastasis; cathepsin D; cathepsin L epithelial ovarian cancer; angiogenesis; metastasis; cathepsin D; cathepsin L
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pranjol, M.Z.I.; Gutowski, N.; Hannemann, M.; Whatmore, J. The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. Biomolecules 2015, 5, 3260-3279.

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