Next Article in Journal
Global N-linked Glycosylation is Not Significantly Impaired in Myoblasts in Congenital Myasthenic Syndromes Caused by Defective Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1)
Next Article in Special Issue
Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity
Previous Article in Journal
The La-Related Proteins, a Family with Connections to Cancer
Previous Article in Special Issue
Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(4), 2723-2757; doi:10.3390/biom5042723

The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation

Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre, Avenida Andalucía S/N, Madrid 28041, Spain
Author to whom correspondence should be addressed.
Academic Editor: Ivana Vancurova
Received: 14 August 2015 / Revised: 23 September 2015 / Accepted: 9 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue Transcriptional Regulation of Pro-Inflammatory Genes)
View Full-Text   |   Download PDF [849 KB, uploaded 16 October 2015]   |  


Chronic inflammation is a common process connecting pathologies that vary in their etiology and pathogenesis such as cancer, autoimmune diseases, and infections. The response of the immune system to tissue damage involves a carefully choreographed series of cellular interactions between immune and non-immune cells. In recent years, it has become clear that stromal resident cells have an essential role perpetuating the inflammatory environment and dictating in many cases the outcome of inflammatory based pathologies. Signal transduction pathways remain the main focus of study to understand how stimuli contribute to perpetuating the inflammatory response, mainly due to their potential role as therapeutic targets. However, molecular events orchestrated in the nucleus by transcription factors add additional levels of complexity and may be equally important for understanding the phenotypic differences of activated stromal components during the chronic inflammatory process. In this review, we focus on the contribution of transcription factors to the selective regulation of inducible proinflammatory genes, with special attention given to the regulation of the stromal fibroblastic cell function and response. View Full-Text
Keywords: inflammation; stroma; fibroblast; transcription; cancer; arthritis; NF-κB; STAT; HIF-1α; AP-1 inflammation; stroma; fibroblast; transcription; cancer; arthritis; NF-κB; STAT; HIF-1α; AP-1

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Valin, A.; Pablos, J.L. The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation. Biomolecules 2015, 5, 2723-2757.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top