Special Issue "Transcriptional Regulation of Pro-Inflammatory Genes"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 April 2015)
Cytokines, chemokines, their receptors, and other inflammatory mediators are essential for a proper immune response during infection. Yet, their increased expression is a hallmark of chronic inflammatory disorders, metabolic disorders, and many types of cancer, highlighting the need for stringent regulation of pro-inflammatory gene expression. The nuclear factor-κB (NFκB) family of transcription factors is a central coordinator of the pro-inflammatory gene expression.
While tremendous progress has been made in understanding the pathways and mechanisms leading to NFkB activation, many unanswered questions remain regarding the mechanisms responsible for selectivity and termination of NFκB responses, modulation of NFκB-dependent transcription by post-translational modification of NFκB subunits and their interactions with other transcription factors and regulators, and metabolic regulation of inflammatory gene expression.
This issue intends to present original research articles and up-to-date reviews about all aspects of the transcriptional regulation of inflammatory genes, with a special focus on the regulation of NFκB-dependent inflammatory genes in cancer and metabolic disorders.
We look forward to reading your contributions,
Prof. Dr. Ivana Vancurova
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cytokine receptors
- transcriptional regulation
- metabolic disorders