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Biomolecules 2015, 5(4), 2701-2722; doi:10.3390/biom5042701

The La-Related Proteins, a Family with Connections to Cancer

1
Ovarian Cancer Research Centre, Institute for Reproductive and Developmental Biology, Imperial College, Du Cane Road, London W12 0HS, UK
2
Department of Oncology, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LE, UK
*
Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 6 August 2015 / Revised: 21 September 2015 / Accepted: 7 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
View Full-Text   |   Download PDF [528 KB, uploaded 16 October 2015]   |  

Abstract

The evolutionarily-conserved La-related protein (LARP) family currently comprises Genuine La, LARP1, LARP1b, LARP4, LARP4b, LARP6 and LARP7. Emerging evidence suggests each LARP has a distinct role in transcription and/or mRNA translation that is attributable to subtle sequence variations within their La modules and specific C-terminal domains. As emerging research uncovers the function of each LARP, it is evident that La, LARP1, LARP6, LARP7 and possibly LARP4a and 4b are dysregulated in cancer. Of these, LARP1 is the first to be demonstrated to drive oncogenesis. Here, we review the role of each LARP and the evidence linking it to malignancy. We discuss a future strategy of targeting members of this protein family as cancer therapy. View Full-Text
Keywords: cancer; LARP; LARP1; transcription; mRNA; translation; proliferation; RNA-binding; RBP; SS-B cancer; LARP; LARP1; transcription; mRNA; translation; proliferation; RNA-binding; RBP; SS-B
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Stavraka, C.; Blagden, S. The La-Related Proteins, a Family with Connections to Cancer. Biomolecules 2015, 5, 2701-2722.

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