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Biomolecules 2015, 5(4), 2207-2222; doi:10.3390/biom5042207

Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Department of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
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Author to whom correspondence should be addressed.
Academic Editor: Jürg Bähler
Received: 17 July 2015 / Revised: 2 September 2015 / Accepted: 8 September 2015 / Published: 24 September 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
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Abstract

Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation. View Full-Text
Keywords: gene expression; post-transcriptional control; RNA-binding protein; microRNA; ribonucleoprotein complex; combinatorial control gene expression; post-transcriptional control; RNA-binding protein; microRNA; ribonucleoprotein complex; combinatorial control
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Iadevaia, V.; Gerber, A.P. Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs. Biomolecules 2015, 5, 2207-2222.

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