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Biomolecules 2015, 5(3), 1618-1633; doi:10.3390/biom5031618

Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player

1
Laboratory of Infection and Prevention, Institute for Virus research, Kyoto University, 53 Shogoin, Kawara-Cho, Sakyo-Ku, Kyoto 606-8507, Japan
2
AMED-CREST, Japan Agency for Medical Research and Development-Core Research for Engineering, Science, and Technology, Kyoto 606-8501, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Ivana Vancurova
Received: 12 May 2015 / Revised: 15 June 2015 / Accepted: 24 June 2015 / Published: 22 July 2015
(This article belongs to the Special Issue Transcriptional Regulation of Pro-Inflammatory Genes)
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Abstract

Transcriptional regulation of inflammatory gene expression has been at the forefront of studies of innate immunity and is coordinately regulated by transcription factors, including NF-κB, and chromatin modifiers. The growing evidence for involvement of chromatin in the regulation of gene expression in innate immune cells, has uncovered an evolutionarily conserved role of microbial sensing and chromatin remodeling. Toll-like receptors and RIG-I-like receptors trigger these signaling pathways leading to transcriptional expression of a set of genes involved in inflammation. Tightly regulated control of this gene expression is a paramount, and often foremost, goal of most biological endeavors. In this review, we will discuss the recent progress about the molecular mechanisms governing control of pro-inflammatory gene expression by an evolutionarily conserved novel nuclear protein Akirin2 in macrophages and its emergence as an essential link between NF-κB and chromatin remodelers for transcriptional regulation. View Full-Text
Keywords: macrophage; innate immunity; inflammation; transcriptional regulation; chromatin remodeling; NF-κB macrophage; innate immunity; inflammation; transcriptional regulation; chromatin remodeling; NF-κB
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tartey, S.; Takeuchi, O. Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player. Biomolecules 2015, 5, 1618-1633.

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