RNA-Mediated Regulation of HMGA1 Function
AbstractThe high mobility group protein A1 (HMGA1) is a master regulator of chromatin structure mediating its major gene regulatory activity by direct interactions with A/T-rich DNA sequences located in the promoter and enhancer regions of a large variety of genes. HMGA1 DNA-binding through three AT-hook motifs results in an open chromatin structure and subsequently leads to changes in gene expression. Apart from its significant expression during development, HMGA1 is over-expressed in virtually every cancer, where HMGA1 expression levels correlate with tumor malignancy. The exogenous overexpression of HMGA1 can lead to malignant cell transformation, assigning the protein a key role during cancerogenesis. Recent studies have unveiled highly specific competitive interactions of HMGA1 with cellular and viral RNAs also through an AT-hook domain of the protein, significantly impacting the HMGA1-dependent gene expression. In this review, we discuss the structure and function of HMGA1-RNA complexes during transcription and epigenomic regulation and their implications in HMGA1-related diseases. View Full-Text
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Benecke, A.G.; Eilebrecht, S. RNA-Mediated Regulation of HMGA1 Function. Biomolecules 2015, 5, 943-957.
Benecke AG, Eilebrecht S. RNA-Mediated Regulation of HMGA1 Function. Biomolecules. 2015; 5(2):943-957.Chicago/Turabian Style
Benecke, Arndt G.; Eilebrecht, Sebastian. 2015. "RNA-Mediated Regulation of HMGA1 Function." Biomolecules 5, no. 2: 943-957.