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Biomolecules 2015, 5(2), 943-957; doi:10.3390/biom5020943

RNA-Mediated Regulation of HMGA1 Function

1
Université Pierre et Marie Curie, CNRS UMR 7224, 7 quai Saint Bernard, Paris 75005, France
2
Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 31 March 2015 / Accepted: 5 May 2015 / Published: 14 May 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
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Abstract

The high mobility group protein A1 (HMGA1) is a master regulator of chromatin structure mediating its major gene regulatory activity by direct interactions with A/T-rich DNA sequences located in the promoter and enhancer regions of a large variety of genes. HMGA1 DNA-binding through three AT-hook motifs results in an open chromatin structure and subsequently leads to changes in gene expression. Apart from its significant expression during development, HMGA1 is over-expressed in virtually every cancer, where HMGA1 expression levels correlate with tumor malignancy. The exogenous overexpression of HMGA1 can lead to malignant cell transformation, assigning the protein a key role during cancerogenesis. Recent studies have unveiled highly specific competitive interactions of HMGA1 with cellular and viral RNAs also through an AT-hook domain of the protein, significantly impacting the HMGA1-dependent gene expression. In this review, we discuss the structure and function of HMGA1-RNA complexes during transcription and epigenomic regulation and their implications in HMGA1-related diseases. View Full-Text
Keywords: HMGA1; non-coding RNA; 7SK RNA; HIV-1 TAR; transcription; chromatin HMGA1; non-coding RNA; 7SK RNA; HIV-1 TAR; transcription; chromatin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Benecke, A.G.; Eilebrecht, S. RNA-Mediated Regulation of HMGA1 Function. Biomolecules 2015, 5, 943-957.

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