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Biomolecules 2015, 5(2), 528-544; doi:10.3390/biom5020528

Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control

1
Medical Research Council Toxicology Unit, Lancaster Rd, Leicester LE1 9HN, UK
2
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Nicolas Cabrera 1, Madrid 28049, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 23 March 2015 / Revised: 1 April 2015 / Accepted: 9 April 2015 / Published: 17 April 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
View Full-Text   |   Download PDF [2183 KB, uploaded 17 April 2015]   |  

Abstract

Gemin5 is a RNA-binding protein (RBP) that was first identified as a peripheral component of the survival of motor neurons (SMN) complex. This predominantly cytoplasmic protein recognises the small nuclear RNAs (snRNAs) through its WD repeat domains, allowing assembly of the SMN complex into small nuclear ribonucleoproteins (snRNPs). Additionally, the amino-terminal end of the protein has been reported to possess cap-binding capacity and to interact with the eukaryotic initiation factor 4E (eIF4E). Gemin5 was also shown to downregulate translation, to be a substrate of the picornavirus L protease and to interact with viral internal ribosome entry site (IRES) elements via a bipartite non-canonical RNA-binding site located at its carboxy-terminal end. These features link Gemin5 with translation control events. Thus, beyond its role in snRNPs biogenesis, Gemin5 appears to be a multitasking protein cooperating in various RNA-guided processes. In this review, we will summarise current knowledge of Gemin5 functions. We will discuss the involvement of the protein on translation control and propose a model to explain how the proteolysis fragments of this RBP in picornavirus-infected cells could modulate protein synthesis. View Full-Text
Keywords: Gemin5; RNA-binding proteins; translation control; IRES elements; snRNPs; picornavirus infection; Gemin5 proteolysis Gemin5; RNA-binding proteins; translation control; IRES elements; snRNPs; picornavirus infection; Gemin5 proteolysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Piñeiro, D.; Fernandez-Chamorro, J.; Francisco-Velilla, R.; Martinez-Salas, E. Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control. Biomolecules 2015, 5, 528-544.

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