Next Article in Journal
Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization
Next Article in Special Issue
RNA-Binding Proteins: Splicing Factors and Disease
Previous Article in Journal
Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies
Previous Article in Special Issue
Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control
Article Menu

Export Article

Open AccessReview
Biomolecules 2015, 5(2), 758-774; doi:10.3390/biom5020758

RNA Binding Proteins that Control Human Papillomavirus Gene Expression

Department of Laboratory Medicine, Lund University, Lund 22184, Sweden
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: André P. Gerber
Received: 17 March 2015 / Revised: 15 April 2015 / Accepted: 21 April 2015 / Published: 5 May 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
View Full-Text   |   Download PDF [182 KB, uploaded 5 May 2015]   |  

Abstract

The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the very top of the epithelium. Such productive infections are normally cleared within 18–24 months. In rare cases, the HPV infection is stuck in the early stage of the infection. Such infections may give rise to cervical lesions that can progress to cancer, primarily cancer of the uterine cervix. Since cancer progression is strictly linked to HPV gene expression, it is of interest to understand how HPV gene expression is regulated. Cis-acting HPV RNA elements and cellular RNA-binding proteins control HPV mRNA splicing and polyadenylation. These interactions are believed to play a particularly important role in the switch from early to late gene expression, thereby contributing to the pathogenesis of HPV. Indeed, it has been shown that the levels of various RNA binding proteins change in response to differentiation and in response to HPV induced cervical lesions and cancer. Here we have compiled published data on RNA binding proteins involved in the regulation of HPV gene expression. View Full-Text
Keywords: HPV; papillomavirus; splicing; polyadenylation; SR proteins; hnRNP; SRSF1; SRSF9; hnRNP A1; hnRNP D HPV; papillomavirus; splicing; polyadenylation; SR proteins; hnRNP; SRSF1; SRSF9; hnRNP A1; hnRNP D
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kajitani, N.; Schwartz, S. RNA Binding Proteins that Control Human Papillomavirus Gene Expression. Biomolecules 2015, 5, 758-774.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top