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Biomolecules 2015, 5(2), 1151-1168; doi:10.3390/biom5021151

CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants

Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546-0312, USA
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Academic Editor: André P. Gerber
Received: 30 March 2015 / Revised: 26 May 2015 / Accepted: 29 May 2015 / Published: 8 June 2015
(This article belongs to the Special Issue RNA-Binding Proteins—Structure, Function, Networks and Disease)
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Abstract

Post-transcriptional processing, involving cleavage of precursor messenger RNA (pre mRNA), and further incorporation of poly(A) tail to the 3' end is a key step in the expression of genetic information. Alternative polyadenylation (APA) serves as an important check point for the regulation of gene expression. Recent studies have shown widespread prevalence of APA in diverse systems. A considerable amount of research has been done in characterizing different subunits of so-called Cleavage and Polyadenylation Specificity Factor (CPSF). In plants, CPSF30, an ortholog of the 30 kD subunit of mammalian CPSF is a key polyadenylation factor. CPSF30 in the model plant Arabidopsis thaliana was reported to possess unique biochemical properties. It was also demonstrated that poly(A) site choice in a vast majority of genes in Arabidopsis are CPSF30 dependent, suggesting a pivotal role of this gene in APA and subsequent regulation of gene expression. There are also indications of this gene being involved in oxidative stress and defense responses and in cellular signaling, suggesting a role of CPSF30 in connecting physiological processes and APA. This review will summarize the biochemical features of CPSF30, its role in regulating APA, and possible links with cellular signaling and stress response modules. View Full-Text
Keywords: mRNA 3' end formation; alternative polyadenylation; cleavage and polyadenylation specificity factor (CPSF); CPSF30; stress response mRNA 3' end formation; alternative polyadenylation; cleavage and polyadenylation specificity factor (CPSF); CPSF30; stress response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chakrabarti, M.; Hunt, A.G. CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants. Biomolecules 2015, 5, 1151-1168.

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