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Biomolecules 2015, 5(2), 1020-1034; doi:10.3390/biom5021020

Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation?

Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
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Author to whom correspondence should be addressed.
Academic Editor: Ivana Vancurova
Received: 20 April 2015 / Accepted: 12 May 2015 / Published: 26 May 2015
(This article belongs to the Special Issue Transcriptional Regulation of Pro-Inflammatory Genes)
View Full-Text   |   Download PDF [165 KB, uploaded 26 May 2015]   |  

Abstract

Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T-lymphocytes. Because of the powerful actions of these chemokines, precise transcriptional control is required. In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet β-cells, which include contributions from the NF-κB and STAT1 pathways. We further discuss increased chemokine expression in pancreatic islets during autoimmune-mediated and obesity-related development of diabetes. View Full-Text
Keywords: chemokine; diabetes; inflammation; islet; transcription chemokine; diabetes; inflammation; islet; transcription
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Burke, S.J.; Collier, J.J. Transcriptional Regulation of Chemokine Genes: A Link to Pancreatic Islet Inflammation? Biomolecules 2015, 5, 1020-1034.

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