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Biocatalysis for Biobased Chemicals
Biomolecules 2013, 3(4), 870-888; doi:10.3390/biom3040870

Biotechnological Applications of Transglutaminases

1 Chimie, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, Québec, H3T 1J4, Canada 2 CGCC, the Center in Green Chemistry and Catalysis, Montréal, H3A 0B8, Canada 3 PROTEO, the Québec Network for Protein Function, Structure and Engineering, Québec, G1V 0A6, Canada 4 Biochimie, Université de Montréal, 2900 Boulevard Edouard-Montpetit, Montréal, Québec, H3T 1J4, Canada
* Author to whom correspondence should be addressed.
Received: 12 September 2013 / Revised: 10 October 2013 / Accepted: 11 October 2013 / Published: 22 October 2013
(This article belongs to the Special Issue Enzymes and Their Biotechnological Applications)
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In nature, transglutaminases catalyze the formation of amide bonds between proteins to form insoluble protein aggregates. This specific function has long been exploited in the food and textile industries as a protein cross-linking agent to alter the texture of meat, wool, and leather. In recent years, biotechnological applications of transglutaminases have come to light in areas ranging from material sciences to medicine. There has also been a substantial effort to further investigate the fundamentals of transglutaminases, as many of their characteristics that remain poorly understood. Those studies also work towards the goal of developing transglutaminases as more efficient catalysts. Progress in this area includes structural information and novel chemical and biological assays. Here, we review recent achievements in this area in order to illustrate the versatility of transglutaminases.
Keywords: biocatalysis; transglutaminase; protein modification; protein labeling biocatalysis; transglutaminase; protein modification; protein labeling
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Rachel, N.M.; Pelletier, J.N. Biotechnological Applications of Transglutaminases. Biomolecules 2013, 3, 870-888.

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