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SUMO Wrestles with Recombination
Department of Biology, Masaryk University, Brno 62500, Czech Republic
National Centre for Biomolecular Research, Masaryk University, Brno 62500, Czech Republic
International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne’s University Hospital in Brno, Brno 62500, Czech Republic
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 10 June 2012; in revised form: 27 June 2012 / Accepted: 13 July 2012 / Published: 25 July 2012
Abstract: DNA double-strand breaks (DSBs) comprise one of the most toxic DNA lesions, as the failure to repair a single DSB has detrimental consequences on the cell. Homologous recombination (HR) constitutes an error-free repair pathway for the repair of DSBs. On the other hand, when uncontrolled, HR can lead to genome rearrangements and needs to be tightly regulated. In recent years, several proteins involved in different steps of HR have been shown to undergo modification by small ubiquitin-like modifier (SUMO) peptide and it has been suggested that deficient sumoylation impairs the progression of HR. This review addresses specific effects of sumoylation on the properties of various HR proteins and describes its importance for the homeostasis of DNA repetitive sequences. The article further illustrates the role of sumoylation in meiotic recombination and the interplay between SUMO and other post-translational modifications.
Keywords: SUMO; homologous recombination; double-strand break; meiosis
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Cite This Article
MDPI and ACS Style
Altmannová, V.; Kolesár, P.; Krejčí, L. SUMO Wrestles with Recombination. Biomolecules 2012, 2, 350-375.
Altmannová V, Kolesár P, Krejčí L. SUMO Wrestles with Recombination. Biomolecules. 2012; 2(3):350-375.
Altmannová, Veronika; Kolesár, Peter; Krejčí, Lumír. 2012. "SUMO Wrestles with Recombination." Biomolecules 2, no. 3: 350-375.