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Metabolites 2018, 8(1), 21; doi:10.3390/metabo8010021

Nanoparticle-Assisted Metabolomics

Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
Campus Chemical Instrument Center, The Ohio State University, Columbus, OH 43210, USA
Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Received: 7 February 2018 / Revised: 6 March 2018 / Accepted: 9 March 2018 / Published: 13 March 2018
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Understanding and harnessing the interactions between nanoparticles and biological molecules is at the forefront of applications of nanotechnology to modern biology. Metabolomics has emerged as a prominent player in systems biology as a complement to genomics, transcriptomics and proteomics. Its focus is the systematic study of metabolite identities and concentration changes in living systems. Despite significant progress over the recent past, important challenges in metabolomics remain, such as the deconvolution of the spectra of complex mixtures with strong overlaps, the sensitive detection of metabolites at low abundance, unambiguous identification of known metabolites, structure determination of unknown metabolites and standardized sample preparation for quantitative comparisons. Recent research has demonstrated that some of these challenges can be substantially alleviated with the help of nanoscience. Nanoparticles in particular have found applications in various areas of bioanalytical chemistry and metabolomics. Their chemical surface properties and increased surface-to-volume ratio endows them with a broad range of binding affinities to biomacromolecules and metabolites. The specific interactions of nanoparticles with metabolites or biomacromolecules help, for example, simplify metabolomics spectra, improve the ionization efficiency for mass spectrometry or reveal relationships between spectral signals that belong to the same molecule. Lessons learned from nanoparticle-assisted metabolomics may also benefit other emerging areas, such as nanotoxicity and nanopharmaceutics. View Full-Text
Keywords: nanoparticles; metabolomics; bioanalysis; NMR; MS nanoparticles; metabolomics; bioanalysis; NMR; MS

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, B.; Xie, M.; Bruschweiler-Li, L.; Brüschweiler, R. Nanoparticle-Assisted Metabolomics. Metabolites 2018, 8, 21.

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