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Metabolites 2014, 4(3), 547-571; doi:10.3390/metabo4030547
Review

Metabolomics for Biomarker Discovery in Gastroenterological Cancer

1,* , 1
, 1
, 1
, 1
 and 1,2,*
Received: 9 April 2014; in revised form: 11 June 2014 / Accepted: 25 June 2014 / Published: 7 July 2014
(This article belongs to the Special Issue Metabolomics and Biotechnology)
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Abstract: The study of the omics cascade, which involves comprehensive investigations based on genomics, transcriptomics, proteomics, metabolomics, etc., has developed rapidly and now plays an important role in life science research. Among such analyses, metabolome analysis, in which the concentrations of low molecular weight metabolites are comprehensively analyzed, has rapidly developed along with improvements in analytical technology, and hence, has been applied to a variety of research fields including the clinical, cell biology, and plant/food science fields. The metabolome represents the endpoint of the omics cascade and is also the closest point in the cascade to the phenotype. Moreover, it is affected by variations in not only the expression but also the enzymatic activity of several proteins. Therefore, metabolome analysis can be a useful approach for finding effective diagnostic markers and examining unknown pathological conditions. The number of studies involving metabolome analysis has recently been increasing year-on-year. Here, we describe the findings of studies that used metabolome analysis to attempt to discover biomarker candidates for gastroenterological cancer and discuss metabolome analysis-based disease diagnosis.
Keywords: metabolomics; biomarker; serum; gastroenterological cancer; mass spectrometry metabolomics; biomarker; serum; gastroenterological cancer; mass spectrometry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nishiumi, S.; Suzuki, M.; Kobayashi, T.; Matsubara, A.; Azuma, T.; Yoshida, M. Metabolomics for Biomarker Discovery in Gastroenterological Cancer. Metabolites 2014, 4, 547-571.

AMA Style

Nishiumi S, Suzuki M, Kobayashi T, Matsubara A, Azuma T, Yoshida M. Metabolomics for Biomarker Discovery in Gastroenterological Cancer. Metabolites. 2014; 4(3):547-571.

Chicago/Turabian Style

Nishiumi, Shin; Suzuki, Makoto; Kobayashi, Takashi; Matsubara, Atsuki; Azuma, Takeshi; Yoshida, Masaru. 2014. "Metabolomics for Biomarker Discovery in Gastroenterological Cancer." Metabolites 4, no. 3: 547-571.



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