Metabolites 2012, 2(1), 1-18; doi:10.3390/metabo2010001

Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers

1email, 1,3,* email and 2email
Received: 28 November 2011; in revised form: 21 December 2011 / Accepted: 22 December 2011 / Published: 4 January 2012
(This article belongs to the Special Issue Lipidomics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The lipidome of the liver and the secreted circulating lipoproteins can now be interrogated conveniently by automated mass spectrometric methods. Multivariate analysis of the liver and serum lipid composition in various animal modes or in human patients has pointed to specific molecular species markers. The perturbations of lipid metabolism can be categorized on the basis of three basic pathological mechanisms: (1) an accelerated rate of de novo lipogenesis; (2) perturbation of the peroxisome pathway of ether-lipid and very-long-chain fatty acid biosynthesis; (3) a change in the rate of interconversion of essential omega-3 and -6 polyunsaturated fatty acids. This review provides examples to illustrate the practicalities of lipidomic studies in biomedicine.
Keywords: biomedical lipidomics; pharmacology; biomarkers
PDF Full-text Download PDF Full-Text [509 KB, uploaded 4 January 2012 12:01 CET]

Export to BibTeX |

MDPI and ACS Style

Lamaziere, A.; Wolf, C.; Quinn, P.J. Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers. Metabolites 2012, 2, 1-18.

AMA Style

Lamaziere A, Wolf C, Quinn PJ. Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers. Metabolites. 2012; 2(1):1-18.

Chicago/Turabian Style

Lamaziere, Antonin; Wolf, Claude; Quinn, Peter J. 2012. "Perturbations of Lipid Metabolism Indexed by Lipidomic Biomarkers." Metabolites 2, no. 1: 1-18.

Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert