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Metabolites 2011, 1(1), 21-40; doi:10.3390/metabo1010021
Review

Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics

1
 and 2,*
Received: 8 October 2011; in revised form: 2 November 2011 / Accepted: 4 November 2011 / Published: 11 November 2011
(This article belongs to the Special Issue Lipidomics)
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Abstract: Electrospray ionization mass spectrometry (ESI-MS) has become one of the most popular and powerful technologies to identify and quantify individual lipid species in lipidomics. Meanwhile, quantitative analysis of lipid species by ESI-MS has also become a major obstacle to meet the challenges of lipidomics. Herein, we discuss the principles, advantages, and possible limitations of different mass spectrometry-based methodologies for lipid quantification, as well as a few practical issues important for accurate quantification of individual lipid species. Accordingly, accurate quantification of individual lipid species, one of the key challenges in lipidomics, can be practically met.
Keywords: electrospray ionization mass spectrometry; lipidomics; quantification; shotgun lipidomics electrospray ionization mass spectrometry; lipidomics; quantification; shotgun lipidomics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yang, K.; Han, X. Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics. Metabolites 2011, 1, 21-40.

AMA Style

Yang K, Han X. Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics. Metabolites. 2011; 1(1):21-40.

Chicago/Turabian Style

Yang, Kui; Han, Xianlin. 2011. "Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry — Meets a Key Challenge in Lipidomics." Metabolites 1, no. 1: 21-40.



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