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Sci. Pharm. 2010, 78(4), 897-908; doi:10.3797/scipharm.1003-19

Polyphenols from Ginkgo biloba

1
Faculty of Pharmacy, Petra University, Airport Street, P O Box 961343 Amman, Jordan
2
Institut fuer pharmazeutische Biologie und Phytochemie, Hittorfstrasse 56, D-48149 Muenster, Germany
3
HerbResearch, Wartbergweg 15, D-86874 Mattsies, Germany
4
School of Pharmacy, Al-Ahliyya Amman University: Amman-19328, Jordan
*
Author to whom correspondence should be addressed.
Received: 23 March 2010 / Accepted: 28 October 2010 / Published: 28 October 2010
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Abstract

By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by 13C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9–10 flavan-3-ol-units.
Keywords: Ginkgo biloba; Polymeric proanthocyanidins; Anti oxidant; Fremy's salt Ginkgo biloba; Polymeric proanthocyanidins; Anti oxidant; Fremy's salt
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

QA’DAN, F.; NAHRSTEDT, A.; SCHMIDT, M.; MANSOOR, K. Polyphenols from Ginkgo biloba. Sci. Pharm. 2010, 78, 897-908.

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