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Sci. Pharm. 2010, 78(4), 897-908; https://doi.org/10.3797/scipharm.1003-19 (registering DOI)
Polyphenols from Ginkgo biloba
Faculty of Pharmacy, Petra University, Airport Street, P O Box 961343 Amman, Jordan
Institut fuer pharmazeutische Biologie und Phytochemie, Hittorfstrasse 56, D-48149 Muenster, Germany
HerbResearch, Wartbergweg 15, D-86874 Mattsies, Germany
School of Pharmacy, Al-Ahliyya Amman University: Amman-19328, Jordan
Author to whom correspondence should be addressed.
Received: 23 March 2010 / Accepted: 28 October 2010 / Published: 28 October 2010
Abstract By Sephadex LH-20 gel chromatography of an extract from Gingko biloba leaves, polymeric proanthocyanidins were eluted after the fractions of flavonol glycosides and biflavone glycosides. A purified proanthocyanidin polymer accounted for 86.6% of the total proanthocyanidins, and for 37.7% of the total antioxidant activity of this leaf extract. For structure elucidation, the polymer was submitted to acidic depolymerization in the presence of phloroglucinol. The structures of the resulting flavan-3-ols and phloroglucinol adducts were determined on the basis of 1D-and reverse 2D-NMR (HSQC, HMBC) spectra of their peracetylated derivatives, MALDI-TOF-MS and CD-spectroscopy. The observations resulting from the degradation with phloroglucinol were confirmed by 13C-NMR spectroscopy of the polymer. The mean molecular weight of the polymeric fraction was estimated to be 9–10 flavan-3-ol-units.
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QA’DAN, F.; NAHRSTEDT, A.; SCHMIDT, M.; MANSOOR, K. Polyphenols from Ginkgo biloba. Sci. Pharm. 2010, 78, 897-908.
QA’DAN F, NAHRSTEDT A, SCHMIDT M, MANSOOR K. Polyphenols from Ginkgo biloba. Scientia Pharmaceutica. 2010; 78(4):897-908.
QA’DAN, Fadi; NAHRSTEDT, Adolf; SCHMIDT, Mathias; MANSOOR, Kenza. 2010. "Polyphenols from Ginkgo biloba." Sci. Pharm. 78, no. 4: 897-908.
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