Next Article in Journal
Polyphenols from Ginkgo biloba
Previous Article in Journal
Interaction of Bioactive Coomassie Brilliant Blue G with Protein: Insights from Spectroscopic Methods
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2010, 78(4), 881-896; doi:10.3797/scipharm.1006-02

Protective Effect of L-Carnitine and Coenzyme Q10 on CCl4-Induced Liver Injury in Rats

1
National Research Centre, El-Behooth St. 12622 Dokki, Giza, Cairo, Egypt
2
King Saud University, KSA, 11495 Ryad, Zip code 22480, Saudi Arabia
3
El-Minia University, Faculty of Pharmacy, Salah Salem St. 61519, Egypt
*
Author to whom correspondence should be addressed.
Received: 9 June 2010 / Accepted: 23 August 2010 / Published: 23 August 2010
Download PDF [903 KB, uploaded 12 October 2016]

Abstract

This study provides an information about the mechanisms of liver injury induced by CCl4, and determines the influence of administration of L-carnitine or/and CoQ10 as prophylactic agents against CCl4 deteriorative effect. The study was carried out on 80 adult male albino rats divided into eight groups, 10 animals each, as follows: four normal groups (control, treated with L-carnitine, treated with CoQ10, and treated with a combination of Lcarnitine and CoQ10) and four liver injury groups treated with CCl4 (control, treated with L-carnitine, treated with CoQ10, and treated with a combination of L-carnitine and CoQ10). Liver injury was induced by s.c. injection of a single dose of CCl4 (1 ml/kg). L-carnitine (50 mg/kg/day) was given i.p. for four successive days 24 hours before CCl4 injection, and CoQ10 (200 mg/kg) was given as a single i.p. dose 24 hours before CCl4 injection. Animals were sacrificed 24 hours after CCl4 injection, blood samples were withdrawn and liver tissue samples were homogenized. The levels of the following parameters were determined: hepatic reduced glutathione, serum ALT and AST, hepatic lipid peroxides, hepatic vitamin C, hepatic and serum total protein, serum albumin, serum sialic acid, serum nitrite, and serum and hepatic total LDH activities and LDH isoenzymes. The obtained data revealed that CCl4 injection produced a significant decrease in reduced glutathione content, vitamin C, total protein and albumin levels. However, there was a significant increase in serum ALT and AST activities, lipid peroxides, sialic acid, nitric oxide, serum and hepatic total LDH activities. On the other hand, groups treated with L-carnitine or/and CoQ10 prior to CCl4 injection showed an improvement in most parameters when compared with cirrhotic control group. It has been concluded that L-carnitine and coenzyme Q10 have a pronounced prophylactic effect against liver damage induced by halogenated alkanes such as carbon tetrachloride.
Keywords: L-carnitine; Coenzyme Q10; Carbon tetrachloride; Liver; Serum; Rats L-carnitine; Coenzyme Q10; Carbon tetrachloride; Liver; Serum; Rats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

ALI, S.A.; FADDAH, L.; ABDEL-BAKY, A.; BAYOUMI, A. Protective Effect of L-Carnitine and Coenzyme Q10 on CCl4-Induced Liver Injury in Rats. Sci. Pharm. 2010, 78, 881-896.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top