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Sci. Pharm. 2010, 78(4), 909-926; doi:10.3797/scipharm.0912-20

Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base

1
Ashok & Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar-388121, India
2
Department of Pharmaceutics, A. R. College of Pharmacy, Vallabh Vidyanagar-388120, India
3
Department of Chemistry, V. P. & R. P. T. P. Science College, Vallabh Vidyanagar-388120, India
*
Author to whom correspondence should be addressed.
Received: 21 December 2009 / Accepted: 26 September 2010 / Published: 26 September 2010
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Abstract

Cefadroxil drug loaded biopolymeric films of chitosan-furfural schiff base were prepared by reacting chitosan with furfural in presence of acetic acid and perchloric acid respectively for the external use. Prepared films were evaluated for their strength, swelling index, thickness, drug content, uniformity, tensile strength, percent elongation, FTIR spectral analysis and SEM. The results of in vitro diffusion studies revealed that the films exhibited enhanced drug diffusion as compared to the films prepared using untreated chitosan. The films also demonstrated good to moderate antibacterial activities against selective gram positive and gram negative bacteria.
Keywords: Cefadroxil; Biopolymeric films; Schiff base of chitosan-furfural; In vitro drug release Cefadroxil; Biopolymeric films; Schiff base of chitosan-furfural; In vitro drug release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DIXIT, R.B.; UPLANA, R.A.; PATEL, V.A.; DIXIT, B.C.; PATEL, T.S. Development and Evaluation of Cefadroxil Drug Loaded Biopolymeric Films Based on Chitosan-Furfural Schiff Base. Sci. Pharm. 2010, 78, 909-926.

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