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Sci. Pharm.
Volume 78
Issue 3
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Sci. Pharm., Volume 78, Issue 3 (September 2010) – 203 articles , Pages 397-744

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244 KiB  
Editorial
Scientia Pharmaceutica, Autorenhinweise 2010
by Sci. Pharm. Editorial Office
Sci. Pharm. 2010, 78(3), 731-744; https://doi.org/10.3797/scipharm.aut-10-03 - 12 Jul 2010
Viewed by 894
Abstract
Die Zeitschrift Scientia Pharmaceutica (www.scipharm.at) erscheint vierteljährlich jeweils am Quartalsende und ist ein Medium zur Publikation von Originalarbeiten, Kurzmit-teilungen und ausgewählten Übersichtsarbeiten aus allen wissenschaftlichen Disziplinen der Pharmazie und angrenzenden Gebieten sowie der pharmazeutischen Praxis. [...]
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87 KiB  
Book Review
"Mikroskopischer Farbatlas pflanzlicher Drogen"
by Bettina Rahfeld
Sci. Pharm. 2010, 78(3), 730; https://doi.org/10.3797/scipharm.br-10-04 - 12 Jul 2010
Viewed by 953
Abstract
n/a Full article
88 KiB  
Book Review
"Classics in Spectroscopy"
by Stefan Berger and Dieter Sicker
Sci. Pharm. 2010, 78(3), 729; https://doi.org/10.3797/scipharm.br-10-03 - 12 Jul 2010
Viewed by 968
Abstract
n/a Full article
129 KiB  
Conference Report
Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter
by T. R. B. GRANDJEAN, J. T. W. YATES and M. J. CHAPPELL
Sci. Pharm. 2010, 78(3), 727-728; https://doi.org/10.3797/scipharm.cespt.8.POT12 - 12 Jul 2010
Viewed by 868
Abstract
A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
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130 KiB  
Conference Report
P-gp Inhibitory Potential of Phospholipids
by S. SIMON and R. SCHUBERT
Sci. Pharm. 2010, 78(3), 726; https://doi.org/10.3797/scipharm.cespt.8.POT11 - 12 Jul 2010
Viewed by 889
Abstract
Introduction: Oral drug administration is mainly regulated by the step of intestinal absorption. [...]
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130 KiB  
Conference Report
Impact of Heat Stress on the Cellular Activity and Culturability of Probiotic Microorganisms
by S. SALAR-BEHZADI, S. TOEGEL, M. HOFRICHTER, I. ALTENBURGER, S. STUMMER, M. BASHOLLI, M. WIRTH, F. M. UNGER and H. VIERNSTEIN
Sci. Pharm. 2010, 78(3), 725; https://doi.org/10.3797/scipharm.cespt.8.POT10 - 12 Jul 2010
Viewed by 885
Abstract
The essential manufacturing step of probiotic products involves dehydration of microorganisms, resulting in cellular stabilization and improved formulation and storage characteristics. [...]
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159 KiB  
Conference Report
Density Functional Theory Calculations on Methylated β-Cyclodextrins
by H. VIERNSTEIN, A. KARPFEN, E. LIEDL, W. SNOR and P. WOLSCHANN
Sci. Pharm. 2010, 78(3), 724; https://doi.org/10.3797/scipharm.cespt.8.POT09 - 12 Jul 2010
Cited by 1 | Viewed by 832
Abstract
Density functional theory studies at the B3LYP/6-31G(d,p) and M06-2X/6- 31G(d,p) levels have been used to determine the geometries and the enthalpies of formation of several methylated β-cyclodextrins. [...]
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101 KiB  
Conference Report
Interactions Of Different Sartans with the Bilayer Interface Studied by Saxs
by M. RAPPOLT, B. SARTORI, A. HODZIC, G. PABST and T. MAVROMOUSTAKOS
Sci. Pharm. 2010, 78(3), 723; https://doi.org/10.3797/scipharm.cespt.8.POT08 - 12 Jul 2010
Viewed by 861
Abstract
This work presents a thorough investigation of the interaction of the novel synthetic pyrrolidinone analog MMK3 and other SARTANS (losartan, valsartan and candesartan) with the model membrane system of dipalmitoylphosphatidylcholine (DPPC). [...]
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125 KiB  
Conference Report
Defining Carbohydrate Targets on Osteoarthritic Chondrocytes using RT-qPCR and LC-ESI-MS
by S.Q. WU, S. TOEGEL, M. PABST, J. GRASS, C. CHIARI, F. M. UNGER, F. ALTMANN and H. VIERNSTEIN
Sci. Pharm. 2010, 78(3), 722; https://doi.org/10.3797/scipharm.cespt.8.POT07 - 12 Jul 2010
Viewed by 902
Abstract
Multiple carbohydrate structures in the chondrocyte glycocalyx can serve as targets for biorecognitive lectins. [...]
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132 KiB  
Conference Report
Modern Dressings for Wound Healing
by R. ROŠIC, J. KRISTL and S. BAUMGARTNER
Sci. Pharm. 2010, 78(3), 721; https://doi.org/10.3797/scipharm.cespt.8.POT06 - 12 Jul 2010
Viewed by 874
Abstract
Aim: Wound healing is a complex process with many potential factors that can delay healing. Full article
130 KiB  
Conference Report
The Stability of Salmon Calcitonin Against Trypsin, Chymotrypsin and Neutrophil Elastase in Human Lung Epithelial Cells
by L. BAGINSKI, S. T. BUCKLEY, U. BAKOWSKY and C. EHRHARDT
Sci. Pharm. 2010, 78(3), 720; https://doi.org/10.3797/scipharm.cespt.8.POT05 - 12 Jul 2010
Viewed by 820
Abstract
At least three enzymes (i. e., trypsin, chymotrypsin and neutrophil elastase) are responsible for the degradation of salmon calcitonin (sCT) in the human body [1]. [...]
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104 KiB  
Conference Report
Natural Surfactant of Alkyl Polyglucoside Type: A Physicochemical Characterization of New Mixed Emulsifier
by M. LUKIC, I. JAKSIC, R. DANIELS, G. VULETA and S. SAVIC
Sci. Pharm. 2010, 78(3), 719; https://doi.org/10.3797/scipharm.cespt.8.POT04 - 12 Jul 2010
Viewed by 1022
Abstract
In the light of the current trend for natural surfactants to be used as emulsifiers [1], a physicochemical characterization of a new mixed alkyl polyglucoside (APG) emulsifier (Arahidyl&Behenyl alcohol&Arahidyl glucoside) was performed. [...]
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130 KiB  
Conference Report
A Coupled Kinetic-Dynamic Model Characterising Cell Cycle Response to an Anti-Cancer Agent
by M. I. ATARI, M. J. CHAPPELL, R. J. ERRINGTON, P. J. SMITH and N. D. EVANS
Sci. Pharm. 2010, 78(3), 718; https://doi.org/10.3797/scipharm.cespt.8.POT03 - 12 Jul 2010
Viewed by 889
Abstract
Topotecan (TPT) is a semi-synthetic derivative of the natural extract camptothecin, which has been found to act as an inhibitor of the DNA enzyme topoisomerase I in a specific and reversible fashion. [...]
Full article
138 KiB  
Conference Report
Development of Intermediate Layer with Improved Diffusional Barrier
by M. T. JAKLIČ and R. JUREČIČ
Sci. Pharm. 2010, 78(3), 717; https://doi.org/10.3797/scipharm.cespt.8.POT02 - 12 Jul 2010
Cited by 1 | Viewed by 938
Abstract
Delayed release dosage form development usually requires an effective intermediate layer for separation of acid liable drug and acidic gastric polymer. [...]
Full article
167 KiB  
Conference Report
The Potential of Sucrose Esters to be used as Oral Absorption Enhancers
by L. KIS, A. SZŰTS, N. OTOMO, P. SZABÓ-RÉVÉSZ and M. A. DELI
Sci. Pharm. 2010, 78(3), 716; https://doi.org/10.3797/scipharm.cespt.8.POT01 - 12 Jul 2010
Cited by 3 | Viewed by 1380
Abstract
Overcoming biological barriers, including the gastrointestinal epithelial barriers, is a great challenge for pharmaceutical research. [...]
Full article
100 KiB  
Conference Report
Protein Characterization in Solution by Small-Angle X-Ray Scattering
by H. SANTNER
Sci. Pharm. 2010, 78(3), 715; https://doi.org/10.3797/scipharm.cespt.8.PPAT26 - 12 Jul 2010
Viewed by 868
Abstract
For many biomedical applications of proteins the knowledge of the threedimensional structure of proteins is of great importance. [...]
Full article
141 KiB  
Conference Report
Application of 14N NQR to the Study of Sulfanilamide, Piroxicam, and Nifedipine Polymorphism
by Z. LAVRIČ, J. PIRNAT, J. LUŽNIK, J. SELIGER, V. ŽAGAR, Z. TRONTELJ and S. SRČIČ
Sci. Pharm. 2010, 78(3), 714; https://doi.org/10.3797/scipharm.cespt.8.PPAT25 - 12 Jul 2010
Viewed by 983
Abstract
14N NQR is a new method in pharmacy that has a potential to establish itself as an additional and valuable analytical tool for characterizing solid state of a substance [1]. [...]
Full article
102 KiB  
Conference Report
Morphologically Directed Raman Spectroscopy as a Novel Tool to Monitor Changes in Particle Size and Shape in Solid Dosage Blends and Formulations
by C. L. LEVOGUER, L. KIDDER and K. HABER
Sci. Pharm. 2010, 78(3), 713; https://doi.org/10.3797/scipharm.cespt.8.PPAT24 - 12 Jul 2010
Cited by 1 | Viewed by 1013
Abstract
One of the key steps in the manufacturing of solid oral dosage formulations is the blending of several ingredients in powdered form which are then processed further to achieve the final dosage form. [...]
Full article
104 KiB  
Conference Report
Caffeine Nucleation Detection Using a Matrix of External Turbidity Probes: Bulk Video Imaging (BVI)
by L. L. SIMON, Z. K. NAGY and K. HUNGERBUHLER
Sci. Pharm. 2010, 78(3), 712; https://doi.org/10.3797/scipharm.cespt.8.PPAT23 - 12 Jul 2010
Viewed by 1010
Abstract
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement [...] Read more.
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. [...]
Full article
146 KiB  
Conference Report
Mechanical Influences During Dissolution Testing in a Novel Peristaltic Movement Simulating Stirring Device
by M. BOGATAJ, A. GLAVAČ, N. NAGELJ KOVAČIČ and A. MRHAR
Sci. Pharm. 2010, 78(3), 711; https://doi.org/10.3797/scipharm.cespt.8.PPAT22 - 12 Jul 2010
Cited by 1 | Viewed by 1092
Abstract
Mechanical stress caused by gastrointestinal motility might have a great impact on drug release from oral dosage forms. [...]
Full article
130 KiB  
Conference Report
Innovative Concepts for Personnel Locks in Clean Room Technology
by S. LIEBMINGER, D. SUZZI, S. FRASER, G. SCHINAGL, S. RADL, L. OBERAUNER, M. AICHNER, M. CARDINALE, J. KHINAST and G. BERG
Sci. Pharm. 2010, 78(3), 710; https://doi.org/10.3797/scipharm.cespt.8.PPAT21 - 12 Jul 2010
Viewed by 971
Abstract
Existing concepts for personnel locks in clean rooms are characterized by cost and time consuming procedures. [...]
Full article
167 KiB  
Conference Report
Application of Dynamic Neural Networks and Fuzzy Algorithms in the Modeling of Drug Release
by J. PETROVIĆ, S. IBRIĆ, G. BETZ and Z. ĐURIĆ
Sci. Pharm. 2010, 78(3), 709; https://doi.org/10.3797/scipharm.cespt.8.PPAT20 - 12 Jul 2010
Viewed by 876
Abstract
The aim of the presented study is to propose the utilization of dynamic neural networks and fuzzy algorithms as in silico tools for prediction of drug release rate from hydrophilic and lipid matrix tablets. Full article
100 KiB  
Conference Report
Characterization of Biomedical Surfaces by Streaming Potential Measurements
by T. LUXBACHER
Sci. Pharm. 2010, 78(3), 708; https://doi.org/10.3797/scipharm.cespt.8.PPAT19 - 12 Jul 2010
Viewed by 847
Abstract
The knowledge of surface charge and the isoelectric point is important for many biomedical applications. [...]
Full article
151 KiB  
Conference Report
Enzyme-Catalyzed Synthesis of 2-Azido-2-deoxy-D-glucose under Catalysis by Recombinant Cellobiose Phosphorylase (CeP)
by B. LUBURA, N. GABRA, P. STARKL, H. VIERNSTEIN and F. M. UNGER
Sci. Pharm. 2010, 78(3), 707; https://doi.org/10.3797/scipharm.cespt.8.PPAT18 - 12 Jul 2010
Viewed by 914
Abstract
The use of enzyme-catalyzed reactions for the synthesis of sugar substrates represents a more desirable approach in terms of “green chemistry”. [...]
Full article
130 KiB  
Conference Report
Multidisciplinary Approach on Characterizing Composites of Vinpocetine and Crospovidone Obtained by Solid State Activation
by D. HASA, D. VOINOVICH, B. PERISSUTTI, A. BONIFACIO, M. GRASSI, E. FRANCESCHINIS, S. DALL’ACQUA, M. SPEH and J. PLAVEC
Sci. Pharm. 2010, 78(3), 706; https://doi.org/10.3797/scipharm.cespt.8.PPAT17 - 12 Jul 2010
Viewed by 899
Abstract
The poorly-soluble Vinpocetine was successfully coground with micronized crospovidone in a planetary mill, which allowed an enhancement of bioavailability through a solid-state activation. [...]
Full article
130 KiB  
Conference Report
Evaluation of Sodium Naproxen Hydrated Forms by Isoconversional Analysis
by L. MALAJ, V. MARTENA, A. CORRIDONI, C. BACCHIOCCHI and P. DI MARTINO
Sci. Pharm. 2010, 78(3), 705; https://doi.org/10.3797/scipharm.cespt.8.PPAT16 - 12 Jul 2010
Viewed by 1053
Abstract
Sodium naproxen (SN) exists in an anhydrous form and in four different hydrated forms: one monohydrate (MSN), two dehydrates (DSN and CSN) and one tetrahydrate (TSN). [...]
Full article
124 KiB  
Conference Report
A Simple High-Throughput Method for Determination of Pregabalin in Pharmaceutical Dosage Forms using a Microplate Fluorescence Reader
by T. VOVK, B. MARTINC and I. GRABNAR
Sci. Pharm. 2010, 78(3), 704; https://doi.org/10.3797/scipharm.cespt.8.PPAT15 - 12 Jul 2010
Cited by 2 | Viewed by 942
Abstract
Pregabalin is a structural analogue of γ-aminobutyric acid approved for treatment of neuropathic pain, as adjunctive therapy for partial seizures, and in generalized anxiety disorder. [...]
Full article
131 KiB  
Conference Report
Tailored Stationary Phases for Continuous Electro-Chromatographic Separation of APIs
by H. GRUBER-WOELFLER, P. W. FEENSTRA, M.-G. BRAUNBRUCK, R. LASKOWSKI, H. J. BART and J. G. KHINAST
Sci. Pharm. 2010, 78(3), 703; https://doi.org/10.3797/scipharm.cespt.8.PPAT14 - 12 Jul 2010
Viewed by 880
Abstract
Highly purified organic materials are essential in various fields, including the fine-chemical, pharmaceutical and food industry. [...]
Full article
130 KiB  
Conference Report
In Vitro-In Silico Tools to Identify Biorelevant Dissolution Specifications for the Selected Poorly-Soluble Model Drugs
by S. GRBIC, J. PAROJCIC and Z. DJURIC
Sci. Pharm. 2010, 78(3), 702; https://doi.org/10.3797/scipharm.cespt.8.PPAT13 - 12 Jul 2010
Viewed by 890
Abstract
Introduction: The most commonly used drug physicochemical property to access its in vivo performance is in vitro dissolution of a drug product. Full article
154 KiB  
Conference Report
Application of Experimental Design for Screening Study of Dissolution Test Conditions: Levothyroxine Sodium Immediate-Release Tablets
by I. KOCIC, I. HOMSEK and M. DACEVIC
Sci. Pharm. 2010, 78(3), 701; https://doi.org/10.3797/scipharm.cespt.8.PPAT12 - 12 Jul 2010
Viewed by 986
Abstract
The aim of the study was to present an example of experimental design application to set up the dissolution test conditions for the two immediaterelease products of levothyroxine sodium (L-Na) with proven bioequivalence: the generic product A and the reference product B [1, [...] Read more.
The aim of the study was to present an example of experimental design application to set up the dissolution test conditions for the two immediaterelease products of levothyroxine sodium (L-Na) with proven bioequivalence: the generic product A and the reference product B [1, 2]. [...]
Full article
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