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Sci. Pharm. 2010, 78(3), 727-728; doi:10.3797/scipharm.cespt.8.POT12

Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter

1
School of Engineering, Warwick University, Coventry, United Kingdom
2
AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom
*
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
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Abstract

A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

GRANDJEAN, T.R.B.; YATES, J.T.W.; CHAPPELL, M.J. Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter. Sci. Pharm. 2010, 78, 727-728.

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