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Sci. Pharm. 2010, 78(3), 727-728; doi:10.3797/scipharm.cespt.8.POT12 (registering DOI)
Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter
School of Engineering, Warwick University, Coventry, United Kingdom
AstraZeneca R&D, Alderley Park, Cheshire, United Kingdom
Author to whom correspondence should be addressed.
Received: 12 July 2010 / Accepted: 12 July 2010 / Published: 12 July 2010
Abstract A mathematical model has been developed describing the pharmacokinetics of Hoechst 33342 following administration into a culture medium containing a population of transfected cells (HEK293 hBCRP) with a potent inhibitor of the BCRP, Fumitremorgin C (FTC), present. [...]
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GRANDJEAN, T.R.B.; YATES, J.T.W.; CHAPPELL, M.J. Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter. Sci. Pharm. 2010, 78, 727-728.
GRANDJEAN TRB, YATES JTW, CHAPPELL MJ. Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter. Scientia Pharmaceutica. 2010; 78(3):727-728.
GRANDJEAN, T. R. B.; YATES, J. T. W.; CHAPPELL, M. J. 2010. "Compartmental Modelling of the Pharmacokinetics of an Efflux Transporter." Sci. Pharm. 78, no. 3: 727-728.
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