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Sci. Pharm. 2009, 77(Posters (PO)), 218; https://doi.org/10.3797/scipharm.oephg.21.PO-19 (registering DOI)
Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Abstract A diversity of disease processes and conditions such as Alzheimer´s disease, schizophrenia, epilepsy and stroke – although they are caused by different mechanism – share one common target: the NMDA-receptor . Recent studies reported the presence and the participation of this glutamate-gated ion-channel in major regulatory mechanisms at the blood-brain barrier (BBB). In order to show the functionability of this receptor and his effects on the BBB, we used an in vitro model based on human cell line ECV304 .
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FREIDL, M.; NEUHAUS, W.; WIRTH, M.; GABOR, F.; NOE, C.R. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier. Sci. Pharm. 2009, 77, 218.
FREIDL M, NEUHAUS W, WIRTH M, GABOR F, NOE CR. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier. Scientia Pharmaceutica. 2009; 77(Posters (PO)):218.
FREIDL, M.; NEUHAUS, W.; WIRTH, M.; GABOR, F.; NOE, C. R. 2009. "Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier." Sci. Pharm. 77, Posters (PO): 218.
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