Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier
1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
2
PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria
3
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(7), 218; https://doi.org/10.3797/scipharm.oephg.21.PO-19
Submission received: 16 April 2009
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Accepted: 16 April 2009
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Published: 16 April 2009
Abstract
A diversity of disease processes and conditions such as Alzheimer´s disease, schizophrenia, epilepsy and stroke – although they are caused by different mechanism – share one common target: the NMDA-receptor [1]. Recent studies reported the presence and the participation of this glutamate-gated ion-channel in major regulatory mechanisms at the blood-brain barrier (BBB). In order to show the functionability of this receptor and his effects on the BBB, we used an in vitro model based on human cell line ECV304 [2].
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MDPI and ACS Style
FREIDL, M.; NEUHAUS, W.; WIRTH, M.; GABOR, F.; NOE, C.R. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier. Sci. Pharm. 2009, 77, 218. https://doi.org/10.3797/scipharm.oephg.21.PO-19
AMA Style
FREIDL M, NEUHAUS W, WIRTH M, GABOR F, NOE CR. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier. Scientia Pharmaceutica. 2009; 77(Posters (PO)):218. https://doi.org/10.3797/scipharm.oephg.21.PO-19
Chicago/Turabian StyleFREIDL, M., W. NEUHAUS, M. WIRTH, F. GABOR, and C. R. NOE. 2009. "Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier" Scientia Pharmaceutica 77, Posters (PO): 218. https://doi.org/10.3797/scipharm.oephg.21.PO-19
