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Sci. Pharm. 2009, 77(Posters (PO)), 218; doi:10.3797/scipharm.oephg.21.PO-19 (registering DOI)

Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier

1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
2
PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria
3
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

A diversity of disease processes and conditions such as Alzheimer´s disease, schizophrenia, epilepsy and stroke – although they are caused by different mechanism – share one common target: the NMDA-receptor [1]. Recent studies reported the presence and the participation of this glutamate-gated ion-channel in major regulatory mechanisms at the blood-brain barrier (BBB). In order to show the functionability of this receptor and his effects on the BBB, we used an in vitro model based on human cell line ECV304 [2].
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

FREIDL, M.; NEUHAUS, W.; WIRTH, M.; GABOR, F.; NOE, C.R. Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier. Sci. Pharm. 2009, 77, 218.

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