Synthesis of a Building Block for Oligopeptide-Oligonucleotide Conjugates

DIRIN, M.; WINKLER, J.; URBAN, E.; NOE, C. R.

doi:10.3797/scipharm.oephg.21.PO-18

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Abstract

16 April 2009

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Synthesis of a Building Block for Oligopeptide-Oligonucleotide Conjugates

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Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria

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Sci. Pharm.2009, 77(7), 217;https://doi.org/10.3797/scipharm.oephg.21.PO-18

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Abstract

Antisense and siRNA oligonucleotides have been widely used in the past decade as an efficient gene-silencing tool in molecular biological investigations. However, their therapeutic application has hitherto been hampered by their poor pharmacokinetic properties.

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