Next Article in Journal
Transport of NSAIDs across the Blood-Brain Barrier in vitro
Previous Article in Journal
Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier
Article Menu

Article Versions

Export Article

Open AccessAbstract
Sci. Pharm. 2009, 77(Posters (PO)), 219; doi:10.3797/scipharm.oephg.21.PO-20 (registering DOI)

Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2

1
PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria
2
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
3
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Download PDF [202 KB, uploaded 12 May 2017]

Abstract

The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. One of the main efflux transporter proteins at the BBB is P-glycoprotein (P-gP) also known as ABCB1 or MDR1. Recently, transport studies with antidepressants suggested presence and functional activity of P-gP in an in vitro model of the BBB based on porcine cell line PBMEC/C1-2 [2]. Due to the important role of P-gP for the transport barrier function of the BBB, the presence and functionability of P-gP was investigated in cell line PBMEC/C1-2 maybe leading to an in vitro BBB model suitable for P-gP substrate screening.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

NEUHAUS, W.; STESSL, M.; STRIZSIK, E.; BENNANI-BAITI, B.; WIRTH, M.; MANDIKOVA, J.; PAWLOWITSCH, R.; TÖGEL, S.; WINKLER, J.; GABOR, F.; NOE, C.R. Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2. Sci. Pharm. 2009, 77, 219.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top