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Diseases 2016, 4(1), 11; doi:10.3390/diseases4010011

Antioxidants and Cardiovascular Risk Factors

Department of Biology, Ecology and Earth Sciences (DiBEST), University of Calabria, 87036 Italy
Academic Editor: Esra Capanoglu
Received: 15 December 2015 / Revised: 3 February 2016 / Accepted: 5 February 2016 / Published: 17 February 2016
View Full-Text   |   Download PDF [204 KB, uploaded 17 February 2016]

Abstract

Cardiovascular disease (CVD), the world’s primary cause of death and disability, represents a global health problem and involves a great public financial commitment in terms of both inability to work and pharmaceutical costs. CVD is characterized by a cluster of disorders, associated with complex interactions between multiple risk factors. The early identification of high cardiovascular risk subjects is one of the main targets of primary prevention in order to reduce the adverse impact of modifiable factors, from lifestyle changes to pharmacological treatments. The cardioprotective effect of food antioxidants is well known. Indeed, a diet rich in fruits and vegetables results in an increase in serum antioxidant capacity and a decrease in oxidative stress. In contrast, studies on antioxidant supplementation, even those that are numerically significant, have revealed no clear benefit in prevention and therapy of CVD. Both short- and long-term clinical trials have failed to consistently support cardioprotective effects of supplemental antioxidant intake. The aim of this review is to evaluate the antioxidant effects on the main cardiovascular risk factors including hypertension, dyslipidemia, diabetes. View Full-Text
Keywords: cardiovascular disease; antioxidants; oxidative stress cardiovascular disease; antioxidants; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pellegrino, D. Antioxidants and Cardiovascular Risk Factors. Diseases 2016, 4, 11.

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