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Hepatocellular Carcinoma: Past and Future of Molecular Target Therapy
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Diseases 2016, 4(1), 10; doi:10.3390/diseases4010010

Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future

1
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore 117609, Singapore
2
Lion TCR Private Limited Singapore, Singapore 069113, Singapore
3
Emerging Infectious Diseases (EID) Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen L. Chan
Received: 16 November 2015 / Revised: 28 January 2016 / Accepted: 4 February 2016 / Published: 15 February 2016
(This article belongs to the Special Issue Targeted Therapy of Hepatocellular Carcinoma: Present and Future)
View Full-Text   |   Download PDF [523 KB, uploaded 15 February 2016]   |  

Abstract

Cancer immunotherapy using a patient’s own T cells redirected to recognize and kill tumor cells has achieved promising results in metastatic melanoma and leukemia. This technique involves harnessing a patient’s T cells and then delivering a gene that encodes a new T cell receptor (TCR) or a chimeric antigen receptor (CAR) that allow the cells to recognize specific cancer antigens. The prospect of using engineered T cell therapy for persistent viral infections like hepatitis B virus (HBV) and their associated malignancies is promising. We recently tested in a first-in-man clinical trial, the ability of HBV-specific TCR-redirected T cells to target HBsAg-productive hepatocellular carcinoma (HCC) and demonstrated that these redirected T cells recognized HCC cells with HBV–DNA integration [1] We discuss here the possibility to use HBV-specific TCR-redirected T cells targeting hepatitis B viral antigens as a tumor specific antigen in patients with HBV-related HCC, and the potential challenges facing the development of this new immunotherapeutic strategy. View Full-Text
Keywords: immunotherapy; liver tumor; HBV; T cell engineering immunotherapy; liver tumor; HBV; T cell engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Koh, S.; Tan, A.T.; Li, L.; Bertoletti, A. Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future. Diseases 2016, 4, 10.

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